瑞香科沉香属植物中梓烷型倍半萜及其重排衍生物
Zizaane-Type Sesquiterpenoids and Their Rearranged Derivatives from Agarwood of an Plant.
机构信息
School of Life Sciences, Hainan University, Haikou 570228, China.
Hainan Engineering Research Center of Agarwood, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China.
出版信息
Molecules. 2021 Dec 29;27(1):198. doi: 10.3390/molecules27010198.
Nine new sesquiterpenoids (-) were isolated from ethyl ether extract of agarwood originated from sp., including three novel sesquiterpenoids (-) derived from zizaane, together with six zizaane-type sesquiterpenoids (-). All structures were unambiguously elucidated based on 1D and 2D NMR spectra as well as by HRESIMS data. The absolute configuration of sesquiterpenoids was determined by comparison of the experimental and computed ECD spectra. In vitro anti-inflammatory assessment showed that compound exhibited inhibition of NO production in LPS-stimulated RAW264.7 cells with an IC value of 62.22 ± 1.27 μM.
从 sp. 来源的沉香乙醚提取物中分离得到 9 种新的倍半萜类化合物（-），包括 3 种新型的来源于荞麦烷的倍半萜类化合物（-），以及 6 种荞麦烷型倍半萜类化合物（-）。所有结构均基于 1D 和 2D NMR 光谱以及 HRESIMS 数据得到明确阐明。通过比较实验和计算的 ECD 光谱确定了倍半萜类化合物的绝对构型。体外抗炎评估表明，化合物 对 LPS 刺激的 RAW264.7 细胞中 NO 生成的抑制作用，IC 值为 62.22 ± 1.27 μM。
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