Institute of Tropical Agriculture and Forestry, Hainan University, Haikou 570228, PR China; Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, PR China; Hainan Engineering Research Center of Agarwood, 571101 Haikou, PR China.
Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, PR China; Hainan Engineering Research Center of Agarwood, 571101 Haikou, PR China.
Fitoterapia. 2019 Jun;135:79-84. doi: 10.1016/j.fitote.2019.04.007. Epub 2019 Apr 14.
Six 8,12-epoxyguaiane sesquiterpenes (1-6), together with two known 2-(2-phenylethyl)chromone derivatives (7-8) were isolated from agarwood originating from Aquilaria filaria. Their structures were established by spectroscopic methods including IR, HRESIMS, 1D, and 2D NMR, and comparison with the published data. The absolute configuration of compound 1 was unambiguously determined by quantum chemical calculation of the electronic circular dichroism (ECD) spectrum. All compounds were tested for their α-glucosidase inhibitory activity and cytotoxicity. Compound 5 showed significant α-glucosidase inhibitory activity with IC value of 253.2 ± 9.7 μM (Acarbose, 743. 4 ± 3.3 μM). Compounds 2-4 displayed weak cytotoxicity against K562 tumor cell lines.
从沉香属白木香中分离得到了 6 个 8,12-环氧乌头烷倍半萜（1-6）和 2 个已知的 2-(2-苯乙基)色酮衍生物（7-8）。通过包括 IR、HRESIMS、1D 和 2D NMR 在内的光谱方法以及与已发表数据的比较，确定了它们的结构。通过量子化学计算电子圆二色性（ECD）光谱，明确确定了化合物 1 的绝对构型。所有化合物均进行了α-葡萄糖苷酶抑制活性和细胞毒性测试。化合物 5 对α-葡萄糖苷酶具有显著的抑制活性，IC 值为 253.2 ± 9.7 μM（阿卡波糖，743.4 ± 3.3 μM）。化合物 2-4 对 K562 肿瘤细胞系表现出较弱的细胞毒性。
