von Holstein C C, Eriksson S B, Källén R
Dept. of Surgery, University of Lund, Sweden.
Scand J Gastroenterol Suppl. 1987;137:71-4. doi: 10.3109/00365528709089767.
In this prospective, randomized, double-blind study the effect of the antifibrinolytic drug tranexamic acid was compared with that of placebo in 154 patients bleeding from verified benign lesions in the stomach and/or duodenum. Three out of 72 patients receiving tranexamic acid underwent emergency surgery, in contrast to 15 out of 82 in the placebo group (p = 0.010). Nineteen patients receiving placebo rebled during admission, as compared with 10 in the treatment group (p = 0.097). The blood transfusion requirement was significantly reduced by tranexamic acid (p = 0.018). Side effects were seen in six patients, of which an uncomplicated deep venous thrombosis was the most severe. It was concluded that tranexamic acid reduces the blood transfusion requirement and the need for emergency surgery in patients bleeding from a benign gastric or duodenal lesion.
在这项前瞻性、随机、双盲研究中，对154例经证实的胃和/或十二指肠良性病变出血患者，比较了抗纤维蛋白溶解药物氨甲环酸与安慰剂的效果。接受氨甲环酸治疗的72例患者中有3例接受了急诊手术，而安慰剂组82例中有15例接受了急诊手术（p = 0.010）。19例接受安慰剂治疗的患者在住院期间再次出血，而治疗组为10例（p = 0.097）。氨甲环酸显著降低了输血需求（p = 0.018）。6例患者出现副作用，其中最严重的是无并发症的深静脉血栓形成。得出的结论是，氨甲环酸可降低良性胃或十二指肠病变出血患者的输血需求和急诊手术需求。
