Isacson S
Dept. of Surgery, Länssjukhuset, Halmstad, Sweden.
Scand J Gastroenterol Suppl. 1987;137:64-6. doi: 10.3109/00365528709089765.
The effect of the antifibrinolytic substance, tranexamic acid, has been studied in 5 double-blind, randomized, placebo-controlled trials in patients with acute upper gastrointestinal bleeding. The results of these trials have varied with regard to blood transfusion requirements and the frequency of operations. All of the studies have shown lower mortality in patients treated with tranexamic acid. Thus tranexamic acid would seem to be indicated in acute upper gastrointestinal bleeding.
在5项针对急性上消化道出血患者的双盲、随机、安慰剂对照试验中，对抗纤溶物质氨甲环酸的效果进行了研究。这些试验在输血需求和手术频率方面结果各异。所有研究均显示，接受氨甲环酸治疗的患者死亡率较低。因此，氨甲环酸似乎适用于急性上消化道出血。
