Yalçin Fatih, Yalçin Hulya, Küçükler Nagehan, Arslan Serbay, Akkuş Oguz, Kurtul Alparslan, Abraham Maria Roselle
Cardiology UCSF Health, Department of Medicine, University of California at San Francisco, San Francisco, CA 94143, USA.
Department of Cardiology, Mustafa Kemal University, Antakya 31100, Turkey.
J Clin Med. 2021 Dec 24;11(1):75. doi: 10.3390/jcm11010075.
Hypertension plays a dominant role in the development of left ventricular (LV) remodeling and heart failure, in addition to being the main risk factor for coronary artery disease. In this review, we focus on the focal geometric and functional tissue aspects of the LV septal base, since basal septal hypertrophy (BSH), as the early imaging biomarker of LV remodeling due to hypertensive heart disease, is detected in cross-sectional clinic studies. In addition, the validation of BSH by animal studies using third generation microimaging and relevant clinical observations are also discussed in the report. Finally, an evaluation of both human and animal quantitative imaging studies and the importance of combined cardiac imaging methods and stress-induction in the separation of adaptive and maladaptive phases of the LV remodeling are pointed out. As a result, BSH, as the early imaging biomarker and quantitative follow-up of functional analysis in hypertension, could possibly contribute to early treatment in a timely fashion in the prevention of hypertensive disease progression to heart failure. A variety of stress stimuli in etiopathogenesis and the difficulty of diagnosing pure hemodynamic overload mediated BSH lead to an absence of the certain prevalence of this particular finding in the population.
高血压不仅是冠状动脉疾病的主要危险因素，在左心室（LV）重构和心力衰竭的发展中也起着主导作用。在本综述中，我们关注左心室间隔基部的局部几何和功能组织方面，因为在横断面临床研究中检测到基底间隔肥厚（BSH），它是高血压性心脏病导致的左心室重构的早期影像学生物标志物。此外，报告中还讨论了使用第三代显微成像的动物研究对BSH的验证以及相关临床观察结果。最后，指出了对人类和动物定量成像研究的评估，以及心脏成像方法和应激诱导在区分左心室重构的适应性和适应不良阶段中的重要性。因此，BSH作为高血压早期影像学生物标志物和功能分析的定量随访指标，可能有助于及时进行早期治疗，预防高血压疾病进展为心力衰竭。病因发病机制中的多种应激刺激以及诊断单纯血流动力学过载介导的BSH的困难，导致这一特定发现在人群中的患病率缺乏确切数据。
