Iannuzzi Arcangelo, Giallauria Francesco, Gentile Marco, Rubba Paolo, Covetti Giuseppe, Bresciani Alessandro, Aliberti Emilio, Cuomo Gilanluigi, Panico Camilla, Tripaldella Maria, Giusti Maria Ausilia, Mattina Alessandro, Iannuzzo Gabriella
Department of Medicine and Medical Specialties, A. Cardarelli Hospital, 80131 Naples, Italy.
Department of Translational Medical Sciences, Federico II University of Naples, 80131 Naples, Italy.
J Clin Med. 2021 Dec 24;11(1):78. doi: 10.3390/jcm11010078.
Atherogenic lipoproteins (particularly, very low-density lipoproteins, VLDL) are associated with subclinical atherosclerosis. The present study aims at evaluating whether routinely analysed lipid parameters are associated with carotid intima-media thickness, a proxy for subclinical atherosclerosis. Lipid parameters from 220 post-menopausal women undergoing ultrasound investigation of the carotid arteries were analysed. Forty-five percent of women showed subclinical atherosclerosis on carotid ultrasound. The mean carotid intima-media thickness was 1.26 ± 0.38 mm. The mean value of the non-HDL-C/HDL-C ratio was 3.1 ± 1.2. Univariate analysis showed a significant association between non-HDL-C/HDL-C ratio and intima-media thickness (r = 0.21, = 0.001). After adjusting for cardiovascular risk factors (age, systolic blood pressure, smoking, body mass index Homeostasis model assessment: insulin resistance and high-sensitivity C-Reactive-Protein), multivariate analysis showed a significant association between non-HDL-C/HDL-C ratio and intima-media thickness (β = 0.039, = 0.04). Logistic regression analysis showed that the highest tertile of the non-HDL-C/HDL-C ratio was associated with the presence of carotid plaques (OR = 3.47, = 0.003). Finally, a strong correlation between non-HDL-C/HDL-C ratio and cholesterol bound to VLDL (r = 0.77, < 0.001) has been found. Non-HDL-C/HDL-C ratio is associated with the presence of carotid atherosclerosis in post-menopausal women and is strongly correlated to VLDL-C levels.
致动脉粥样硬化脂蛋白（特别是极低密度脂蛋白，VLDL）与亚临床动脉粥样硬化相关。本研究旨在评估常规分析的血脂参数是否与颈动脉内膜中层厚度相关，颈动脉内膜中层厚度是亚临床动脉粥样硬化的一个替代指标。对220名接受颈动脉超声检查的绝经后女性的血脂参数进行了分析。45%的女性在颈动脉超声检查中显示有亚临床动脉粥样硬化。颈动脉内膜中层厚度的平均值为1.26±0.38毫米。非高密度脂蛋白胆固醇/高密度脂蛋白胆固醇比值的平均值为3.1±1.2。单因素分析显示非高密度脂蛋白胆固醇/高密度脂蛋白胆固醇比值与内膜中层厚度之间存在显著相关性（r = 0.21，P = 0.001）。在对心血管危险因素（年龄、收缩压、吸烟、体重指数、稳态模型评估：胰岛素抵抗和高敏C反应蛋白）进行校正后，多因素分析显示非高密度脂蛋白胆固醇/高密度脂蛋白胆固醇比值与内膜中层厚度之间存在显著相关性（β = 0.039，P = 0.04）。逻辑回归分析显示，非高密度脂蛋白胆固醇/高密度脂蛋白胆固醇比值的最高三分位数与颈动脉斑块的存在相关（OR = 3.47，P = 0.003）。最后，发现非高密度脂蛋白胆固醇/高密度脂蛋白胆固醇比值与结合到VLDL的胆固醇之间存在强相关性（r = 0.77，P < 0.001）。非高密度脂蛋白胆固醇/高密度脂蛋白胆固醇比值与绝经后女性颈动脉粥样硬化的存在相关，并且与VLDL-C水平密切相关。
