Quadflieg Kirsten, Machado Ana, Haesevoets Sarah, Daenen Marc, Thomeer Michiel, Ruttens David, Spruit Martijn A, Burtin Chris
REVAL-Rehabilitation Research Center, Faculty of Rehabilitation Sciences, Hasselt University, 3590 Diepenbeek, Belgium.
BIOMED-Biomedical Research Institute, Hasselt University, 3590 Diepenbeek, Belgium.
J Clin Med. 2021 Dec 28;11(1):150. doi: 10.3390/jcm11010150.
Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) have a negative impact on patients' health status, including physical function and patient-reported outcomes. We aimed to explore the associations between physical tests and patient-reported outcome measures (PROMs) in hospitalised patients for an AECOPD. Patients were assessed on the day of discharge. Quadriceps force, handgrip strength, short physical performance battery (SPPB), five-repetition sit-to-stand test (5STS), four-meter gait speed test (4MGS), balance test, six-minute walk test (6MWT), COPD Assessment Test (CAT), London Chest Activity of Daily Living scale (LCADL), modified Medical Research Council (mMRC) dyspnea scale, Checklist of Individual Strength (CIS)-fatigue subscale, and Patient Health Questionnaire (PHQ-9) were collected. Sixty-nine patients with an AECOPD were included (54% female; age 69 ± 9 years; FEV 39.2 (28.6-49.1%) predicted). Six-minute walk distance was strongly correlated with mMRC (: -0.64, < 0.0001) and moderately correlated with LCADL total score, subscales self-care and household activities ( ranging from -0.40 to -0.58, < 0.01). Moreover, 4MGS was moderately correlated with mMRC (: -0.49, < 0.0001). Other correlations were weak or non-significant. During a severe AECOPD, physical tests are generally poorly related to PROMs. Therefore, a comprehensive assessment combining both physical tests and PROMs needs to be conducted in these patients to understand their health status.
慢性阻塞性肺疾病急性加重（AECOPD）会对患者的健康状况产生负面影响，包括身体功能和患者报告的结局。我们旨在探讨因AECOPD住院患者的体能测试与患者报告结局指标（PROMs）之间的关联。在出院当天对患者进行评估。收集了股四头肌力量、握力、简短体能表现电池测试（SPPB）、五次坐立试验（5STS）、四米步态速度测试（4MGS）、平衡测试、六分钟步行试验（6MWT）、慢性阻塞性肺疾病评估测试（CAT）、伦敦胸部日常生活活动量表（LCADL）、改良医学研究委员会（mMRC）呼吸困难量表、个人力量清单（CIS）-疲劳子量表和患者健康问卷（PHQ-9）。纳入了69例AECOPD患者（54%为女性；年龄69±9岁；FEV为预测值的39.2（28.6-49.1%））。六分钟步行距离与mMRC呈强相关（r：-0.64，P<0.0001），与LCADL总分、自我护理和家务活动子量表呈中度相关（r范围为-0.40至-0.58，P<0.01）。此外，4MGS与mMRC呈中度相关（r：-0.49，P<0.0001）。其他相关性较弱或无统计学意义。在严重AECOPD期间，体能测试与PROMs通常相关性较差。因此，需要对这些患者进行体能测试和PROMs相结合的综合评估，以了解他们的健康状况。
