Noh Choong-Kyun, Lee Eunyoung, Lee Gil Ho, Lim Sun Gyo, Park Bumhee, Shin Sung Jae, Cheong Jae Youn, Lee Kee Myung
Department of Gastroenterology, Ajou University School of Medicine, Suwon 16499, Korea.
Department of Biomedical Informatics, Ajou University School of Medicine, Suwon 16499, Korea.
J Clin Med. 2021 Dec 31;11(1):230. doi: 10.3390/jcm11010230.
Although regular endoscopic screening may help in early detection of gastric cancer, interval cancer remains a problem in the screening program. This study evaluated the association between regular endoscopic screening and interval cancer detection in the Korean National Cancer Screening Program (KNCSP). We defined three groups (regularly, irregularly, and not screened) according to the screening interval, and the trends in the interval cancer rate (ICR) between the groups were tested using the Cochran-Armitage test. The influence of regular endoscopic screening on the risk of interval cancer was evaluated using multivariable logistic regression. Among the 11,642,410 participants who underwent endoscopy, the overall ICR was 0.36 per 1000 negative screenings. The ICR of the not screened group (0.41) was the highest among the three groups and the risk of interval cancer in this group was 1.68 times higher ( < 0.001) than that in the regularly screened group. Women in their 40s who had regular screening with no history of intestinal metaplasia and gastric polyps would have the lowest probability of having interval cancer (0.005%). Regular participation in endoscopic screening programs for reducing the risk of interval cancer may help to improve the quality of screening programs.
尽管定期内镜筛查可能有助于早期发现胃癌，但间隔期癌仍是筛查计划中的一个问题。本研究评估了韩国国家癌症筛查计划（KNCSP）中定期内镜筛查与间隔期癌检测之间的关联。我们根据筛查间隔定义了三组（定期、不定期和未筛查），并使用 Cochr an - Armitage检验来检测各组之间间隔期癌发生率（ICR）的趋势。使用多变量逻辑回归评估定期内镜筛查对间隔期癌风险的影响。在接受内镜检查的11642410名参与者中，总体ICR为每1000次阴性筛查0.36例。未筛查组的ICR（0.41）在三组中最高，该组间隔期癌的风险比定期筛查组高1.68倍（<0.001）。40多岁有定期筛查且无肠化生和胃息肉病史的女性患间隔期癌的概率最低（0.005%）。定期参与内镜筛查计划以降低间隔期癌风险可能有助于提高筛查计划的质量。
