硅油填充对孔源性视网膜脱离患者中心凹及旁中心凹视网膜厚度的影响：一项回顾性队列研究。

Impact of duration of silicone oil tamponade on foveal and parafoveal thickness in rhegmatogenous retinal detachment: a retrospective cohort study.

机构信息

Kasr Alainy Faculty of Medicine, Cairo University, 108 Alshaheed Ahmed Hamdy St., Madkour, Giza, Cairo, Egypt.

出版信息

Int Ophthalmol. 2024 Apr 2;44(1):167. doi: 10.1007/s10792-024-03096-8.

DOI:10.1007/s10792-024-03096-8

PMID:38565753

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10987340/

Abstract

PURPOSE

To detect and analyze the influence of the duration of tamponade with silicone oil on the foveal and parafoveal thickness in cases of rhegmatogenous retinal detachment.

METHODS

This is a retrospective cohort study of 64 eyes with rhegmatogenous retinal detachment in one eye who underwent pars plana vitrectomy (PPV) with silicone oil injection during the period between January 2019 and December 2021. The patients were divided into 2 groups. Group A with early removal of the silicone oil after 3-4 months and Group B with late removal of the silicone oil (SOR) after 6-8 months. The 2 groups were compared as regards the central foveal (CFT) and parafoveal (PFT) thickness changes from baseline, just before SOR, and after SOR. Changes in best corrected visual acuity (BCVA), relative risk of severe thinning. It was conducted at Kasr Alainy Hospital.

RESULTS

64 eyes were enrolled in the study. Group A included 36 eyes, and group B included 28 eyes. The mean CFT changed insignificantly from 253 ± 52 μm to 252 ± 48 μm after SOR in group A; while it changed significantly from 211 ± 52 μm to 202 ± 46 μm after SOR in group B. The mean PFT decreased insignificantly from 299 ± 39 μm to 297 ± 40 μm in group A, while it decreased significantly from 284 ± 46 μm to 273 ± 44 μm in group B. Lines of improvement of BCVA were 4.11 ± 1.88 in group A, and 2.00 ± 1.24 in group B. Relative risk of severe foveal thinning after SOR was 14.3, and severe parafoveal thinning was 15.43, in group B compared to group A.

CONCLUSION

Longer period of silicone oil tamponade may carry a higher risk for severe foveal and parafoveal thinning after silicone oil removal.

TRIAL REGISTRATION

The study was registered at clinical trial.gov under the title of (Duration of silicone oil tamponade on foveal and parafoveal thickness in Rhegmatogenous Retinal Detachment) with an ID NCT05817630 at April 2023 "retrospectively registered".

摘要

目的

检测和分析硅油填塞时间对孔源性视网膜脱离患者黄斑及旁中心区厚度的影响。

方法

这是一项回顾性队列研究，纳入了 2019 年 1 月至 2021 年 12 月期间因单眼孔源性视网膜脱离在我院接受经睫状体平坦部玻璃体切除术（PPV）联合硅油填充的 64 只眼。将患者分为两组，A 组术后 3-4 个月行硅油取出术，B 组术后 6-8 个月行硅油取出术。比较两组患者从基线、硅油取出前和硅油取出后的中央凹（CFT）和旁中心区（PFT）厚度变化、最佳矫正视力（BCVA）变化、严重变薄的相对风险。

结果

研究共纳入 64 只眼，A 组 36 只眼，B 组 28 只眼。A 组硅油取出后，CFT 从 253±52μm 无明显变化至 252±48μm；B 组硅油取出后，CFT 从 211±52μm 显著下降至 202±46μm。A 组硅油取出后，PFT 从 299±39μm 无明显变化至 297±40μm；B 组硅油取出后，PFT 从 284±46μm 显著下降至 273±44μm。A 组 BCVA 改善线为 4.11±1.88，B 组为 2.00±1.24。B 组硅油取出后严重黄斑区变薄的相对风险为 14.3，严重旁中心区变薄的相对风险为 15.43，均高于 A 组。