Tamang Nirmala, Shrestha Pooja, Khadka Binita, Mondal Monohar Hossain, Saha Bidyut, Bhattarai Ajaya
Department of Chemistry, Mahendra Morang Adarsh Multiple Campus (M.M.A.M.C.), Tribhuvan University, Biratnagar 56613, Nepal.
Central Department of Biotechnology, Tribhuvan University, Kirtipur 44618, Nepal.
Polymers (Basel). 2021 Dec 30;14(1):127. doi: 10.3390/polym14010127.
Polysaccharides, polynucleotides, and polypeptides are basic natural polymers. They have various applications based on their properties. This review mostly discusses the application of natural polymers as emulsion stabilizers. Natural emulsion stabilizers are polymers of amino acid, nucleic acid, carbohydrate, etc., which are derived from microorganisms, bacteria, and other organic materials. Plant and animal proteins are basic sources of natural emulsion stabilizers. Pea protein-maltodextrin and lentil protein feature entrapment capacity up to 88%, (1-10% concentrated), zein proteins feature 74-89% entrapment efficiency, soy proteins in various concentrations increase dissolution, retention, and stability to the emulsion and whey proteins, egg proteins, and proteins from all other animals are applicable in membrane formation and encapsulation to stabilize emulsion/nanoemulsion. In pharmaceutical industries, phospholipids, phosphatidyl choline (PC), phosphatidyl ethanol-amine (PE), and phosphatidyl glycerol (PG)-based stabilizers are very effective as emulsion stabilizers. Lecithin (a combination of phospholipids) is used in the cosmetics and food industries. Various factors such as temperature, pH, droplets size, etc. destabilize the emulsion. Therefore, the emulsion stabilizers are used to stabilize, preserve and safely deliver the formulated drugs, also as a preservative in food and stabilizer in cosmetic products. Natural emulsion stabilizers offer great advantages because they are naturally degradable, ecologically effective, non-toxic, easily available in nature, non-carcinogenic, and not harmful to health.
多糖、多核苷酸和多肽是基本的天然聚合物。它们基于自身特性有多种应用。本综述主要讨论天然聚合物作为乳液稳定剂的应用。天然乳液稳定剂是氨基酸、核酸、碳水化合物等的聚合物,它们源自微生物、细菌和其他有机材料。植物和动物蛋白是天然乳液稳定剂的基本来源。豌豆蛋白 - 麦芽糊精和小扁豆蛋白的包封率高达88%(1 - 10%浓缩),玉米醇溶蛋白的包封效率为74 - 89%,不同浓度的大豆蛋白可提高乳液的溶解性、保留率和稳定性,乳清蛋白、鸡蛋蛋白以及所有其他动物来源的蛋白可用于形成膜和包封以稳定乳液/纳米乳液。在制药行业,基于磷脂、磷脂酰胆碱(PC)、磷脂酰乙醇胺(PE)和磷脂酰甘油(PG)的稳定剂作为乳液稳定剂非常有效。卵磷脂(磷脂的组合)用于化妆品和食品行业。温度、pH值、液滴大小等各种因素会使乳液不稳定。因此,乳液稳定剂用于稳定、保存和安全递送配制好的药物,也用作食品中的防腐剂和化妆品中的稳定剂。天然乳液稳定剂具有很大优势,因为它们可自然降解、生态高效、无毒、在自然界中容易获得、无致癌性且对健康无害。