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聚合物/蛋白质杂化水凝胶的自愈行为

Self-Healing Behavior of Polymer/Protein Hybrid Hydrogels.

作者信息

Bercea Maria

机构信息

"Petru Poni" Institute of Macromolecular Chemistry, 41-A Grigore Ghica Voda Alley, 700487 Iasi, Romania.

出版信息

Polymers (Basel). 2021 Dec 30;14(1):130. doi: 10.3390/polym14010130.

DOI:10.3390/polym14010130
PMID:35012155
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8747654/
Abstract

The paper presents the viscoelastic properties of new hybrid hydrogels containing poly(vinyl alcohol) (PVA), hydroxypropylcellulose (HPC), bovine serum albumin (BSA) and reduced glutathione (GSH). After heating the mixture at 55 °C, in the presence of GSH, a weak network is formed due to partial BSA unfolding. By applying three successive freezing/thawing cycles, a stable porous network structure with elastic properties is designed, as evidenced by SEM and rheology. The hydrogels exhibit self-healing properties when the samples are cut into two pieces; the intermolecular interactions are reestablished in time and therefore the fragments repair themselves. The effects of the BSA content, loaded deformation and temperature on the self-healing ability of hydrogels are presented and discussed through rheological data. Due to their versatile viscoelastic behavior, the properties of PVA/HPC/BSA hydrogels can be tuned during their preparation in order to achieve suitable biomaterials for targeted applications.

摘要

本文介绍了含有聚乙烯醇（PVA）、羟丙基纤维素（HPC）、牛血清白蛋白（BSA）和还原型谷胱甘肽（GSH）的新型混合水凝胶的粘弹性特性。在55°C下加热混合物后，在GSH存在的情况下，由于部分BSA展开而形成弱网络。通过进行三个连续的冷冻/解冻循环，设计出具有弹性特性的稳定多孔网络结构，扫描电子显微镜（SEM）和流变学证明了这一点。当将水凝胶样品切成两块时，它们表现出自愈特性；分子间相互作用会及时重新建立，因此碎片会自行修复。通过流变学数据展示并讨论了BSA含量、加载变形和温度对水凝胶自愈能力的影响。由于其具有多种粘弹性行为，PVA/HPC/BSA水凝胶的特性可在制备过程中进行调整，以获得适用于特定应用的生物材料。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee33/8747654/09430a70f63d/polymers-14-00130-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee33/8747654/6d2dc8fbddae/polymers-14-00130-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee33/8747654/2aa3bf2f453e/polymers-14-00130-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee33/8747654/73461fa8424d/polymers-14-00130-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee33/8747654/fabf0196d6bb/polymers-14-00130-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee33/8747654/18d647e61501/polymers-14-00130-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee33/8747654/56a4c857b008/polymers-14-00130-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee33/8747654/0d2896e796f1/polymers-14-00130-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee33/8747654/b066109fcb91/polymers-14-00130-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee33/8747654/496b6fbd8f37/polymers-14-00130-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee33/8747654/c1f1ebd52385/polymers-14-00130-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee33/8747654/09430a70f63d/polymers-14-00130-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee33/8747654/6d2dc8fbddae/polymers-14-00130-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee33/8747654/2aa3bf2f453e/polymers-14-00130-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee33/8747654/73461fa8424d/polymers-14-00130-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee33/8747654/fabf0196d6bb/polymers-14-00130-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee33/8747654/18d647e61501/polymers-14-00130-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee33/8747654/56a4c857b008/polymers-14-00130-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee33/8747654/0d2896e796f1/polymers-14-00130-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee33/8747654/b066109fcb91/polymers-14-00130-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee33/8747654/496b6fbd8f37/polymers-14-00130-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee33/8747654/c1f1ebd52385/polymers-14-00130-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee33/8747654/09430a70f63d/polymers-14-00130-g010.jpg

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