Plugariu Ioana-Alexandra, Bercea Maria, Gradinaru Luiza Madalina, Rusu Daniela, Lupu Alexandra
"Petru Poni" Institute of Macromolecular Chemistry, 41-A Grigore Ghica Voda Alley, 700487 Iasi, Romania.
Gels. 2023 Jul 16;9(7):580. doi: 10.3390/gels9070580.
Hydrogels are 3D networks with an excellent ability to retain a high amount of water or biological fluids, representing suitable candidates for wound dressing applications. They can provide a protective barrier and a moist environment, facilitating wound treatment. The present paper focuses on physical hydrogels obtained from poly(vinyl alcohol) (PVA) and pullulan (PULL) mixtures in different weight ratios by using the freezing/thawing method. Hybrid hydrogels of similar polymer compositions were prepared in the presence of 0.5% Laponite RD. The influence of polysaccharide and clay addition on the properties of PVA hydrogels was investigated. Scanning electron microscopy showed evidence of the inner porous structure. The viscoelastic properties were investigated in different shear conditions and revealed the influence of the hydrogel composition on the network strength. The swelling behavior was followed in physiological saline solutions at 37 °C and pH = 7.4. For all samples, a quasi-Fickian diffusion mechanism was found. The delivery of neomycin sulfate was studied in similar conditions as for the swelling tests (0.15 M NaCl solutions; 37 °C; pH = 7.4) and different kinetic models were used to determine the release mechanism. The Peppas-Sahlin approach described very well the in vitro drug release mechanism from the polymeric hydrogels in the absence of clay. However, the hybrid polymer/clay hydrogels showed the best fit with the Korsmeyer-Peppas model. According to the present study, the porous membranes containing 40-60% PULL (in absence of clay) are suitable for the release of therapeutic agents at wound sites in physiological conditions.
水凝胶是具有出色能力来保留大量水或生物流体的三维网络，是伤口敷料应用的合适候选材料。它们可以提供保护屏障和潮湿环境，促进伤口治疗。本文重点研究了通过冷冻/解冻方法由不同重量比的聚乙烯醇（PVA）和支链淀粉（PULL）混合物制成的物理水凝胶。在0.5%锂皂石RD存在的情况下制备了聚合物组成相似的杂化水凝胶。研究了多糖和粘土的添加对PVA水凝胶性能的影响。扫描电子显微镜显示了内部多孔结构的证据。在不同剪切条件下研究了粘弹性性能，并揭示了水凝胶组成对网络强度的影响。在37°C和pH = 7.4的生理盐溶液中跟踪溶胀行为。对于所有样品，发现了准菲克扩散机制。在与溶胀测试相似的条件下（0.15 M NaCl溶液；37°C；pH = 7.4）研究了硫酸新霉素的释放，并使用不同的动力学模型来确定释放机制。在没有粘土的情况下，Peppas-Sahlin方法很好地描述了聚合物水凝胶的体外药物释放机制。然而，聚合物/粘土杂化水凝胶与Korsmeyer-Peppas模型拟合得最好。根据本研究，含有40-60% PULL（无粘土）的多孔膜适用于在生理条件下伤口部位治疗剂的释放。
