School of Public Health, Sun Yat-sen University, No. 74 Zhongshan 2nd Road, Guangzhou, Guangdong Province, China.
Guangzhou Twelfth People's Hospital, Guangzhou, 510620, China.
BMC Public Health. 2022 Jan 10;22(1):56. doi: 10.1186/s12889-021-12451-8.
To examine the mediating effect of obesity indicators on the association between daytime napping and type 2 diabetes mellitus (T2DM) qualitatively and quantitatively using baseline data from the Guangzhou Biobank Cohort Study.
Twenty-nine thousand three hundred fifty-five participants aged 50+ years were included in this cross-sectional study. Mediation analysis was used to assess the mediating effect of body mass index (BMI), waist circumference (WC), hip circumference (HC), waist-to-hip ratio (WHR) and waist-to-height ratio (WHtR) on the association between daytime napping and T2DM after adjustment for sex, age, education, occupation, smoking status, alcohol use and physical activity.
The mean (standard deviation) age of participants was 61.5 ( 7.1) years. The prevalence of T2DM and daytime napping was 12.5% and 65.2%, respectively. After adjustment for potential confounders, WC, WHR and WHtR showed partial mediating effects on the association between daytime napping and T2DM, with the proportion (95% confidence interval) of mediation effect being 10.17% (8.14-14.43%), 14.91% (11.95-21.24%) and 9.36% (7.49-13.29%), respectively. No mediating effect of BMI or HC on the association between daytime napping and T2DM was found.
Our results showed significant mediating effects of WC, WHR and WHtR on the association between daytime napping and T2DM, suggesting that waist circumference management could be important in daytime nappers.
利用广州市生物库队列研究的基线数据，定性和定量研究日间小睡与 2 型糖尿病（T2DM）之间的关联的肥胖指标的中介作用。
本横断面研究纳入了 29355 名 50 岁以上的参与者。采用中介分析评估体重指数（BMI）、腰围（WC）、臀围（HC）、腰臀比（WHR）和腰围身高比（WHtR）在日间小睡与 T2DM 之间的关联中的中介作用，调整性别、年龄、教育程度、职业、吸烟状况、饮酒和身体活动后。
参与者的平均（标准差）年龄为 61.5（7.1）岁。T2DM 和日间小睡的患病率分别为 12.5%和 65.2%。在调整潜在混杂因素后，WC、WHR 和 WHtR 对日间小睡与 T2DM 之间的关联表现出部分中介作用，中介效应的比例（95%置信区间）分别为 10.17%（8.14-14.43%）、14.91%（11.95-21.24%）和 9.36%（7.49-13.29%）。BMI 或 HC 对日间小睡与 T2DM 之间的关联没有中介作用。
我们的研究结果表明，WC、WHR 和 WHtR 对日间小睡与 T2DM 之间的关联具有显著的中介作用，这表明腰围管理在日间小睡者中可能很重要。
