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新冠疫情对美国儿科和青少年疫苗接种及儿童健康检查的影响:数据库分析。

Impact of the COVID-19 pandemic on pediatric and adolescent vaccinations and well child visits in the United States: A database analysis.

机构信息

Merck & Co., Inc, 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA.

出版信息

Vaccine. 2022 Jan 31;40(5):706-713. doi: 10.1016/j.vaccine.2021.12.064. Epub 2022 Jan 1.

Abstract

BACKGROUND

The COVID-19 pandemic has disrupted healthcare, including immunization practice and well child visit attendance. Maintaining vaccination coverage is important to prevent disease outbreaks and morbidity. We assessed the impact of the COVID-19 pandemic on pediatric and adolescent vaccination administration and well child visit attendance in the United States.

METHODS

This cross-sectional study used IBM MarketScan Commercial Database (IMC) with Early View (healthcare claims database) and TriNetX Dataworks Global Network (electronic medical records database) from January 2018-March 2021. Individuals ≤ 18 years of age who were enrolled during the analysis month of interest (IMC with Early View) or had ≥ 1 health encounter at a participating institution (TriNetX Dataworks) were included. We calculated the monthly percent difference between well child visit attendance and vaccine administration rates for 10 recommended pediatric/adolescent vaccines in 2020 and 2021 compared with 2018-2019. Data were stratified by the age groups 0-2 years, 4-6 years, and 9-16 years.

RESULTS

In IMC with Early View, the average monthly enrollment for children 0-18 years of age was 5.2 million. In TriNetX Dataworks, 12.2 million eligible individuals were included. Well child visits and vaccinations reached the lowest point in April 2020 compared with 2018-2019. Well child visit attendance and vaccine administration rates were inversely related to age, with initial reductions highest for adolescents and lowest for ages 0-2 years. Rates rebounded in June and September 2020 and stabilized to pre-pandemic levels in Fall 2020. Rates dropped below baseline in early 2021 for groups 0-2 years and 4-6 years.

CONCLUSIONS

We found substantial disruptions in well child visit attendance and vaccination administration for children and adolescents during the COVID-19 pandemic in 2020 and early 2021. Continued efforts are needed to monitor recovery and catch up to avoid outbreaks and morbidity associated with vaccine-preventable diseases.

摘要

背景

COVID-19 大流行扰乱了医疗保健,包括免疫接种实践和儿童常规健康检查的就诊率。保持疫苗接种覆盖率对于预防疾病爆发和发病至关重要。我们评估了 COVID-19 大流行对美国儿科和青少年疫苗接种管理以及儿童常规健康检查就诊率的影响。

方法

本横断面研究使用了 IBM MarketScan 商业数据库(IMC)及其早期视图(医疗保健索赔数据库)和 TriNetX Dataworks 全球网络(电子病历数据库),时间范围为 2018 年 1 月至 2021 年 3 月。分析月份(IMC 及其早期视图)纳入了年龄≤18 岁且在分析月份有登记记录或在参与机构有≥1 次就诊记录的个体。我们计算了 2020 年和 2021 年与 2018-2019 年相比,10 种推荐的儿科/青少年疫苗的儿童常规健康检查就诊率和疫苗接种率的每月百分比差异。数据按年龄组 0-2 岁、4-6 岁和 9-16 岁进行分层。

结果

在 IMC 及其早期视图中,0-18 岁儿童的平均每月登记人数为 520 万。在 TriNetX Dataworks 中,纳入了 1220 万符合条件的个体。与 2018-2019 年相比,儿童常规健康检查和疫苗接种在 2020 年 4 月达到最低点。儿童常规健康检查就诊率和疫苗接种率与年龄呈反比,最初青少年的降幅最大,0-2 岁年龄组的降幅最小。2020 年 6 月和 9 月,这些比率出现反弹,并在 2020 年秋季稳定在大流行前水平。2021 年初,0-2 岁和 4-6 岁组的比率降至基线以下。

结论

我们发现,2020 年和 2021 年初 COVID-19 大流行期间,儿童和青少年的儿童常规健康检查就诊率和疫苗接种管理受到严重干扰。需要继续努力监测恢复情况,以避免与疫苗可预防疾病相关的爆发和发病。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/32b5/8719942/6381396172e8/gr1_lrg.jpg

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