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评估新冠疫情对儿童哮喘发病率的影响。

Evaluating the Impact of the COVID-19 Pandemic on Pediatric Asthma Incidence.

作者信息

Devonshire Ashley L, Guilbert Theresa, Bauer Cindy S, Schmidt Heidi, Davis Stephanie, Hernandez Michelle, Fitzpatrick Anne M, Gaffin Jonathan M, Kattan Meyer, De Aliva, Jackson Daniel J, Mauger David, Phipatanakul Wanda, Schwartz Justin T, Sheehan William, Long Dayna, Juarez Lourdes, Bacharier Leonard B, Stokes Jeffrey R, Teach Stephen J, Morgan Wayne J, Martinez Fernando D

机构信息

Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center and University of Cincinnati, Cincinnati, Ohio.

Division of Pulmonary Medicine, Cincinnati Children's Hospital Medical Center and University of Cincinnati, Cincinnati, Ohio.

出版信息

J Allergy Clin Immunol Pract. 2025 Aug;13(8):1952-1959. doi: 10.1016/j.jaip.2025.04.056. Epub 2025 May 14.

Abstract

Multiple early life environmental exposures are thought to influence childhood asthma incidence. The coronavirus disease 2019 (COVID-19) pandemic resulted in changes in air pollution levels and a marked disruption in the circulation of childhood respiratory viruses. Both air pollution and respiratory viruses have been implicated in the development of asthma and early childhood wheeze. Human behavior and daily routine practices, including family gatherings and daycare attendance, were impacted profoundly by the COVID-19 pandemic and the associated mitigation measures. The changes to human behavior and social interactions that occurred during the pandemic have and will likely continue to impact chronic diseases, including the development of asthma. This rostrum explores how childhood asthma incidence might be affected by the COVID-19 pandemic and its associated public health mitigation measures. Recently completed and ongoing clinical trials being conducted in the infant and toddler population and assessing allergic outcomes may be well positioned to examine the impact of the pandemic on asthma incidence and time to asthma onset.

摘要

多种早期生活环境暴露因素被认为会影响儿童哮喘的发病率。2019年冠状病毒病(COVID-19)大流行导致空气污染水平发生变化,并显著扰乱了儿童呼吸道病毒的传播。空气污染和呼吸道病毒都与哮喘和幼儿喘息的发生有关。人类行为和日常活动,包括家庭聚会和日托出勤,受到COVID-19大流行及相关缓解措施的深刻影响。大流行期间发生的人类行为和社会互动变化已经并可能继续影响慢性病,包括哮喘的发生。本讲台探讨了COVID-19大流行及其相关公共卫生缓解措施可能如何影响儿童哮喘发病率。最近在婴幼儿群体中完成的以及正在进行的评估过敏结局的临床试验,可能非常适合研究大流行对哮喘发病率和哮喘发病时间的影响。

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本文引用的文献

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Pediatric Respiratory Syncytial Virus Hospitalizations, 2017-2023.2017-2023 年儿童呼吸道合胞病毒住院情况。
JAMA Netw Open. 2024 Jun 3;7(6):e2416077. doi: 10.1001/jamanetworkopen.2024.16077.
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COVID-19 and Asthma Onset in Children.儿童 COVID-19 与哮喘发作。
Pediatrics. 2024 May 1;153(5). doi: 10.1542/peds.2023-064615.

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