不可逆电穿孔用于肝癌消融：一项荟萃分析。
Irreversible electroporation for liver cancer ablation: A meta analysis.
作者信息
Yu Maoli, Li Sheng
机构信息
Department of Radiology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, 651 Dongfeng Road East, Guangzhou, Guangdong, 510060, PR China.
出版信息
Eur J Surg Oncol. 2022 Jun;48(6):1321-1330. doi: 10.1016/j.ejso.2021.12.015. Epub 2021 Dec 15.
OBJECTIVE
To evaluate the efficacy and safety of IRE in the treatment of hepatic malignant tumors, especially the damage to the gastrointestinal tract, bile ducts, and vital vessels.
METHODS
The relevant literatures published from January 1, 2010 to July 1, 2021 were searched from PubMed and Embase databases. The following keywords were applied: "irreversible electroporation", "IRE", "unresectable Hepa∗ cancer", "ablation" and "ablation therapy".
RESULTS
Twenty-six studies were identified covering 807 participants and 1115 lesions. The complete ablation rate of liver cancer by IRE was 86% (95% CI: 81%-90%). The incidence of IRE-related complications was 23% (95% CI: 17%-28%), but most of them were minor, major complications such as biliary fistula, intestinal fistula and massive hemorrhage were rare.
CONCLUSION
Meta-analysis showed that IRE ablation is safe and effective for liver cancer treatment. Bile duct, intestine and blood vessels adjacent to the tumors are rarely damaged by IRE ablation.
目的
评估不可逆电穿孔（IRE）治疗肝脏恶性肿瘤的疗效和安全性，尤其是对胃肠道、胆管和重要血管的损伤。
方法
从PubMed和Embase数据库检索2010年1月1日至2021年7月1日发表的相关文献。使用了以下关键词：“不可逆电穿孔”、“IRE”、“不可切除的肝癌”、“消融”和“消融治疗”。
结果
共纳入26项研究，涉及807名参与者和1115个病灶。IRE治疗肝癌的完全消融率为86%（95%CI：81%-90%）。IRE相关并发症的发生率为23%（95%CI：17%-28%），但大多数为轻微并发症，胆瘘、肠瘘和大出血等严重并发症罕见。
结论
荟萃分析表明，IRE消融治疗肝癌安全有效。IRE消融很少损伤肿瘤附近的胆管、肠道和血管。
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