CNC - Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal; Centre for Innovation in Biomedicine and Biotechnology (CIBB), University of Coimbra, Coimbra, Portugal; Faculty of Pharmacy, University of Coimbra, Coimbra, Portugal.
CNC - Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal; Centre for Innovation in Biomedicine and Biotechnology (CIBB), University of Coimbra, Coimbra, Portugal.
Trends Mol Med. 2022 Feb;28(2):97-109. doi: 10.1016/j.molmed.2021.12.003. Epub 2022 Jan 7.
The skin is the largest organ and has a key protective role. Similar to any other tissue, the skin is influenced not only by intrinsic/chronological aging, but also by extrinsic aging, triggered by environmental factors that contribute to accelerating the skin aging process. Aged skin shows structural, cellular, and molecular changes and accumulation of senescent cells. These senescent cells can induce or accelerate the age-related dysfunction of other nearby cells from the skin, or from different origins. However, the extent and underlying mechanisms remain unknown. In this opinion, we discuss the possible relevant role of skin senescence in the induction of aging phenotypes to other organs/tissues, contributing to whole-body aging. Moreover, we suggest that topical administration of senolytics/senotherapeutics could counteract the overall whole-body aging phenotype.
皮肤是人体最大的器官，具有关键的保护作用。与其他组织一样，皮肤不仅受到内在/时间相关的老化的影响，还受到环境因素的外在老化的影响，这些环境因素加速了皮肤老化过程。衰老的皮肤表现出结构、细胞和分子的变化，以及衰老细胞的积累。这些衰老细胞可以诱导或加速皮肤或其他来源的附近细胞的与年龄相关的功能障碍。然而，其程度和潜在机制尚不清楚。在本观点中，我们讨论了皮肤衰老在诱导其他器官/组织衰老表型中的可能相关作用，从而导致全身性衰老。此外，我们还提出，局部应用衰老细胞清除剂/衰老治疗剂可能会对抗全身性衰老表型。
