Department of Dermatology, Mayo Clinic, Rochester, Minnesota, USA.
Department of Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, British Columbia, Canada.
Gerontology. 2024;70(1):7-14. doi: 10.1159/000534756. Epub 2023 Oct 25.
As the largest organ in the human body, the skin is continuously exposed to intrinsic and extrinsic stimuli that impact its functionality and morphology with aging. Skin aging entails dysregulation of skin cells and loss, fragmentation, or fragility of extracellular matrix fibers that are manifested macroscopically by wrinkling, laxity, and pigmentary abnormalities. Age-related skin changes are the focus of many surgical and nonsurgical treatments aimed at improving overall skin appearance and health.
As a hallmark of aging, cellular senescence, an essentially irreversible cell cycle arrest with apoptosis resistance and a secretory phenotype, manifests across skin layers by affecting epidermal and dermal cells. Knowledge of skin-specific senescent cells, such as melanocytes (epidermal aging) and fibroblasts (dermal aging), will promote our understanding of age-related skin changes and how to optimize patient outcomes in esthetic procedures.
This review provides an overview of skin aging in the context of cellular senescence and discusses senolytic intervention strategies to selectively target skin senescent cells that contribute to premature skin aging.
皮肤作为人体最大的器官，不断受到内在和外在刺激的影响，随着年龄的增长，其功能和形态也会发生变化。皮肤衰老涉及皮肤细胞的失调以及细胞外基质纤维的丢失、碎片化或脆弱，这些变化在宏观上表现为皱纹、松弛和色素异常。与年龄相关的皮肤变化是许多旨在改善整体皮肤外观和健康的手术和非手术治疗的重点。
作为衰老的标志，细胞衰老，一种具有抗细胞凋亡和分泌表型的基本不可逆的细胞周期停滞，通过影响表皮和真皮细胞在皮肤各层表现出来。对皮肤特异性衰老细胞（如表皮衰老的黑素细胞和真皮衰老的成纤维细胞）的了解，将促进我们对与年龄相关的皮肤变化的理解，以及如何优化美容手术中患者的治疗效果。
本综述概述了细胞衰老背景下的皮肤衰老，并讨论了选择性针对导致皮肤过早衰老的皮肤衰老细胞的衰老细胞清除干预策略。
