Doctoral Degree Program in Marine Biotechnology, National Taiwan Ocean University, Keelung, Taiwan, ROC.
Doctoral Degree Program in Marine Biotechnology, Academia Sinica, Taipei, Taiwan, ROC.
Sci Rep. 2022 Jan 10;12(1):429. doi: 10.1038/s41598-021-04151-5.
Having infected by Helicobacter pylori, the infection often leads to gastritis, gastric ulcer, or even gastric cancer. The disease is typically treated with antibiotics as they used to effectively inhibit or kill H. pylori, thus reducing the incidence of gastric adenoma and cancer to significant extent. H. pylori, however, has developed drug resistance to many clinically used antibiotics over the years, highlighting the crisis of antibiotic failure during the H. pylori treatment. We report here that the fucoidan from Sargassum hemiphyllum can significantly reduce the infection of H. pylori without developing to drug resistance. Fucoidan appears to be a strong anti-inflammation agent as manifested by the RAW264.7 cell model examination. Fucoidan can prohibit H. pylori adhesion to host cells, thereby reducing the infection rate by 60%, especially in post treatment in the AGS cell model assay. Mechanistically, fucoidan intervenes the adhesion of BabA and AlpA of H. pylori significantly lowering the total count of H. pylori and the level of IL-6 and TNF-α in vivo. These results all converge on the same fact that fucoidan is an effective agent in a position to protect the stomach from the H. pylori infection by reducing both the total count and induced inflammation.
感染幽门螺杆菌后，常导致胃炎、胃溃疡，甚至胃癌。该病通常采用抗生素治疗，因为抗生素能有效抑制或杀灭幽门螺杆菌，从而在很大程度上降低胃腺瘤和癌症的发病率。然而，多年来，幽门螺杆菌对许多临床使用的抗生素产生了耐药性，凸显出幽门螺杆菌治疗中抗生素失效的危机。我们在这里报告，半叶马尾藻岩藻聚糖能显著降低幽门螺杆菌的感染，而不会产生耐药性。岩藻聚糖似乎是一种强大的抗炎剂，这在 RAW264.7 细胞模型检查中得到了体现。岩藻聚糖可以阻止幽门螺杆菌黏附宿主细胞，从而使感染率降低 60%，在 AGS 细胞模型检测中尤其在治疗后效果显著。从机制上讲，岩藻聚糖显著干预了幽门螺杆菌的 BabA 和 AlpA 的黏附，从而降低了体内幽门螺杆菌的总数和 IL-6 和 TNF-α 的水平。这些结果都表明岩藻聚糖是一种有效的药物，能够通过降低总计数和诱导炎症来保护胃免受幽门螺杆菌感染。
