Universidad Cardenal Herrera-CEU, Facultad de Veterinaria, Avenida Seminario s/n, 46113 Moncada, Valencia, Spain.
Food Funct. 2020 May 1;11(5):4525-4534. doi: 10.1039/d0fo00768d. Epub 2020 May 12.
Currently, Helicobacter pylori is the unique biological carcinogenic agent. The search for antimicrobial alternatives to antibiotics against this pathogen has been categorized as a priority due to the drastic failure associated with current applied antibiotic therapy. The present study assessed the bioactive antimicrobial capability of fucoidan ("Generally Recognized as Safe" approval - European Commission December 2017) from different species of Phaeophyceae algae (Fucus vesiculosus, Undaria pinnatifida, Macrocystis pyrifera) against H. pylori. All the studied fucoidans showed bacteriostatic and bactericidal effects at the studied concentrations [5-100] μg ml and exposure times [0-7 days]. The most effective anti-H. pylori fucoidan was validated in Caenorhabditis elegans as an in vivo model. C. elegans feed was supplemented with Undaria pinnatifida [0-100] μg ml fucoidan, resulting in a significant improvement in lifespan, lowered H. pylori concentration in the digestive tract, and increased egg-laying pattern. New research lines proposing this compound as an active agent in nutraceutical and preventive novel therapies should be opened.
目前，幽门螺杆菌是唯一的生物致癌剂。由于目前应用的抗生素治疗效果不佳，因此寻找对抗这种病原体的抗生素替代品已被列为优先事项。本研究评估了来自不同种类褐藻（泡叶藻、裙带菜、巨藻）的褐藻糖胶（“一般认为安全”-欧洲委员会 2017 年 12 月批准）对幽门螺杆菌的生物活性抗菌能力。所有研究的褐藻糖胶在研究浓度[5-100]μg ml 和暴露时间[0-7 天]下均显示出抑菌和杀菌作用。最有效的抗幽门螺杆菌褐藻糖胶在秀丽隐杆线虫体内模型中得到了验证。在秀丽隐杆线虫的饲料中添加裙带菜[0-100]μg ml 褐藻糖胶，可显著延长其寿命，降低消化道中幽门螺杆菌的浓度，并增加产卵模式。应该开辟新的研究路线，将该化合物作为营养保健品和预防新型疗法的活性物质。
