College of Chemistry and Environmental Science, Institute of Life Science and Green Development, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education, Chemical Biology Key Laboratory of Hebei Province, Hebei University, Baoding 071002, P. R. China.
Cixi Institute of Biomedical Engineering, International Cooperation Base of Biomedical Materials Technology and Application, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo 315201, P. R. China.
ACS Appl Bio Mater. 2021 Feb 15;4(2):1969-1975. doi: 10.1021/acsabm.0c01597. Epub 2021 Feb 3.
Metal-doped carbon dots (CDs) exhibited promising application in fluorescence and magnetic resonance (MR) imaging, but developing manganese-doped CDs (Mn-CDs) with long wavelength emission and enhanced MR performance is a challenge. Herein, using a one-step solvothermal method, Mn-CDs with redshifted orange emission and enhanced longitudinal relaxation were synthesized for fluorescence and MR imaging. The results indicated that the prepared Mn-CDs had a uniform size distribution, and the average size was 5 nm. Moreover, Mn-CDs possessed a stronger fluorescence performance than Mn-free CDs, and simultaneously, the emission wavelength can redshift from 542 nm (green emission) to 578 nm (orange emission), owing to the increasing N-doping. Because of the movement limit of Mn, Mn-CDs exhibited high T-weighted MR imaging performance with a longitudinal relaxation rate of 12.69 mM·s. The experiments demonstrated their excellent fluorescence and MR imaging with safety and reliability. Therefore, the prepared Mn-CDs with orange emission can be an excellent candidate as a dual-modal nanoprobe for fluorescence and MR imaging.
金属掺杂碳点（CDs）在荧光和磁共振（MR）成像中表现出了有前景的应用，但开发具有长波长发射和增强磁共振性能的锰掺杂 CDs（Mn-CDs）是一个挑战。在此，使用一步溶剂热法，合成了具有红移橙色发射和增强纵向弛豫的 Mn-CDs，用于荧光和磁共振成像。结果表明，所制备的 Mn-CDs 具有均匀的尺寸分布，平均尺寸为 5nm。此外，Mn-CDs 具有比无 Mn-CDs 更强的荧光性能，同时，由于 N 掺杂的增加，发射波长可以从 542nm（绿色发射）红移到 578nm（橙色发射）。由于 Mn 的运动限制，Mn-CDs 表现出高 T1 加权磁共振成像性能，纵向弛豫率为 12.69mM·s-1。实验证明了它们具有良好的荧光和磁共振成像性能，安全性和可靠性。因此，所制备的具有橙色发射的 Mn-CDs 可以作为荧光和磁共振成像的双模式纳米探针的优秀候选者。
