Perevodchikova N I, Gorbunova V A, Lichinitser M R, Moroz L V
Antibiotiki. 1976 Jul;21(7):657-60.
A total of 39 patients with sarcoma of the soft tissues were treated with carminomycin administered intravenously in doses of 10-15 mg twice a week, the total dose being 60-70 mg. The intervals between the courses were 1 month. The objective effect was observed in 17 out of 39 patients, i. e. 43.6%. The tumor decrease was registered in 6 out of 15 patients with leuomyosarcoma, in 3 out of 6 patients with synovial sarcoma, in 2 out of 4 patients with robdomyosarcoma, in 1 out of 4 patients with angiosarcoma, in 1 out of 3 patients with fibrosarcoma, in 1 patient with liposarcoma and in 3 out of 5 patients with stromal sarcoma of the uterus. A necessity for repeated treatment courses in spite of a positive effect or absence of the disease progress is underlined.
共有39例软组织肉瘤患者接受了卡米诺霉素治疗,静脉给药,剂量为每周两次,每次10 - 15毫克,总剂量为60 - 70毫克。疗程间隔为1个月。39例患者中有17例观察到客观疗效,即43.6%。15例平滑肌肉瘤患者中有6例肿瘤缩小,滑膜肉瘤6例中有3例,横纹肌肉瘤4例中有2例,血管肉瘤4例中有1例,纤维肉瘤3例中有1例,脂肪肉瘤1例,子宫间质肉瘤5例中有3例。强调了尽管有积极效果或疾病无进展仍有必要进行重复治疗疗程。