Gustave Roussy, Université Paris-Saclay, 114 rue Edouard Vaillant, Villejuif, France; INSERM U 981, Université Paris-Saclay, 114 rue Edouard Vaillant, Villejuif, France.
Gustave Roussy, Université Paris-Saclay, 114 rue Edouard Vaillant, Villejuif, France; Institute for Integrative Biology of the Cell (I2BC), Université Paris-Saclay, CNRS, CEA, 1 avenue de la Terrasse, Gif-sur-Yvette, France.
Cancer Cell. 2022 Jan 10;40(1):14-16. doi: 10.1016/j.ccell.2021.12.008.
In this issue of Cancer Cell, Newell et al. introduce whole-genome and methylome data to melanoma immunotherapy response analysis. Genome breaks are more frequent in resistant tumors, but the best response classifiers remain mutation burden and interferon-ɣ signature. Clinical translation will need aggregation of many such datasets.
在本期《癌细胞》中，Newell 等人介绍了全基因组和甲基组数据，用于黑色素瘤免疫治疗反应分析。耐药肿瘤中基因组断裂更为频繁，但最佳的反应分类器仍然是突变负担和干扰素-ɣ 特征。临床转化将需要聚合许多这样的数据集。
