Kokubo Nana, Arake Masashi, Yamagishi Kento, Morimoto Yuji, Takeoka Shinji, Ohta Hiroyuki, Fujie Toshinori
PRESTO, Japan Science and Technology Agency, 4-1-8, Honcho, Kawaguchi-shi, Saitama 332-0012, Japan.
School of Life Science and Technology, Tokyo Institute of Technology, B-50, 4259 Nagatsuta-cho, Midori-ku, Yokohama 226-8501, Japan.
ACS Appl Bio Mater. 2019 Jan 22;2(1):20-26. doi: 10.1021/acsabm.8b00574. Epub 2018 Dec 12.
Flexible materials are important for the development of neural probes in recording stable signals (spikes) . Here, we present inkjet-printed, flexible neural probes for spike recording by using polymeric thin films. The neural probes were constructed from 400 nm-thick poly(d,l-lactic acid) nanofilms, inkjet-printed lines consisting of Au and poly(3,4-ethylenedioxythiophene):polystyrenesulfonate nanoinks, and fluoropolymer layers. Microelectrodes were exposed by cutting the edge with a razor. The 6 μm-thick probes were connected to the external amplifiers by gradual increase of stiffness with thickness-dependent manner. The probe was formed into a needle shape, which recorded spikes from mouse thalamus .
柔性材料对于开发能够记录稳定信号（尖峰信号）的神经探针至关重要。在此，我们展示了通过使用聚合物薄膜进行喷墨打印的柔性神经探针，用于尖峰信号记录。这些神经探针由400纳米厚的聚（d，l - 乳酸）纳米薄膜、由金和聚（3,4 - 亚乙基二氧噻吩）：聚苯乙烯磺酸盐纳米墨水组成的喷墨打印线路以及含氟聚合物层构建而成。通过用剃须刀切割边缘来暴露微电极。6微米厚的探针通过以厚度依赖方式逐渐增加刚度与外部放大器相连。该探针被制成针状，用于记录小鼠丘脑的尖峰信号。
