Advanced MRI Section, Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health; Bethesda, MD, United States.
Advanced MRI Section, Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health; Bethesda, MD, United States.
Neuroimage. 2022 Apr 1;249:118888. doi: 10.1016/j.neuroimage.2022.118888. Epub 2022 Jan 10.
During sleep, slow waves of neuro-electrical activity engulf the human brain and aid in the consolidation of memories. Recent research suggests that these slow waves may also promote brain health by facilitating the removal of metabolic waste, possibly by orchestrating the pulsatile flow of cerebrospinal fluid (CSF) through local neural control over vascular tone. To investigate the role of slow waves in the generation of CSF pulsations, we analyzed functional MRI data obtained across the full sleep-wake cycle and during a waking respiratory task. This revealed a novel generating mechanism that relies on the autonomic regulation of cerebral vascular tone without requiring slow electrocortical activity or even sleep. Therefore, the role of CSF pulsations in brain waste clearance may, in part, depend on proper autoregulatory control of cerebral blood flow.
在睡眠过程中，神经电活动的缓慢波席卷大脑，并有助于记忆的巩固。最近的研究表明，这些缓慢波还可以通过促进代谢废物的清除来促进大脑健康，这可能是通过协调脑脊液（CSF）的脉冲式流动来实现的，这种流动是通过局部神经对血管张力的控制来实现的。为了研究慢波在 CSF 脉冲产生中的作用，我们分析了整个睡眠-觉醒周期和清醒呼吸任务期间获得的功能 MRI 数据。这揭示了一种新的产生机制，它依赖于大脑血管张力的自主调节，而不需要慢皮质电活动，甚至不需要睡眠。因此，CSF 脉冲在清除脑废物中的作用可能部分取决于大脑血流的适当自动调节控制。
