Nair Vidhya V, Kish Brianna R, Oshima Hideyuki, Wright Adam M, Wen Qiuting, Schwichtenberg A J, Tong Yunjie
Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, USA.
Graduate School of Engineering and Science, Shibaura Institute of Technology, Japan.
J Cereb Blood Flow Metab. 2025 May 15:271678X251337637. doi: 10.1177/0271678X251337637.
Fluctuations in cerebral blood volume (CBV) are a dominant mechanism aiding cerebrospinal fluid (CSF) movement in the brain during wakefulness and non-rapid eye movement (NREM) sleep. However, it is unclear if the amplitudes of CBV oscillations also change in proportion to the changes in amplitude of CSF movement across specific NREM sleep states. It is also not known if the coupling strength between them varies between NREM sleep states. To investigate these relationships, we measured cerebral hemodynamics and craniad CSF movement at the fourth ventricle simultaneously during wakefulness and NREM sleep states using concurrent Electroencephalography and functional Magnetic Resonance Imaging. We found that the amplitude fluctuations of cerebral hemodynamics and CSF oscillations desynchronize from one another only during deep NREM3 state, despite the strong mechanical coupling between CBV changes and CSF movement, which was consistent across all states. This suggests the existence of a different mechanism, linked to the cortical interstitial volume/resistance change, that regulates the NREM3 CSF inflow into the brain.
脑血容量（CBV）的波动是清醒和非快速眼动（NREM）睡眠期间辅助脑脊液（CSF）在大脑中流动的主要机制。然而，尚不清楚CBV振荡的幅度是否也会随着特定NREM睡眠状态下CSF流动幅度的变化而成比例地改变。也不知道它们之间的耦合强度在NREM睡眠状态之间是否会有所不同。为了研究这些关系，我们在清醒和NREM睡眠状态下，同时使用同步脑电图和功能磁共振成像测量了第四脑室的脑血流动力学和脑脊液向颅侧的流动。我们发现，尽管CBV变化与CSF流动之间存在强大的机械耦合，且这种耦合在所有状态下都是一致的，但脑血流动力学和CSF振荡的幅度波动仅在深度NREM3状态下彼此不同步。这表明存在一种与皮质间质体积/阻力变化相关的不同机制，该机制调节NREM3期间CSF流入大脑。
