种植体周围炎患者与健康患者细胞因子及疱疹病毒水平的评估
Assessment of Cytokine and Herpesvirus Level in Peri-implantitis and Healthy Patients.
作者信息
Sahoo Sanjay Kumar, Jalaluddin Mohammad, Bhuyan Lipsa, Dash Kailash Chandra, Mishra Silpiranjan, Mishra Pallavi
机构信息
Department of Periodontics and Oral Implantology, Kalinga Institute of Dental Sciences, Kalinga Institute of Industrial Technology Deemed to be University, Bhubaneswar, Odisha, India.
Department of Oral and Maxillofacial Pathology and Microbiology, Kalinga Institute of Dental Sciences, Kalinga Institute of Industrial Technology Deemed to be University, Bhubaneswar, Odisha, India.
出版信息
J Pharm Bioallied Sci. 2021 Nov;13(Suppl 2):S1418-S1421. doi: 10.4103/jpbs.jpbs_233_21. Epub 2021 Nov 10.
BACKGROUND
The present study was conducted to assess level of cytokine and herpesvirus in peri-implantitis and healthy patients.
METHODOLOGY
Fifty patients with healthy dental implant (Group I) and dental implant with peri-implantitis (Group II) were enrolled. The level of interleukin (IL)-1 β, IL-2, IL-4, IL-6, MCP-1 and tumor necrosis factor-α (TNF-α), and herpesvirus was estimated.
RESULTS
The mean IL-1 β level was 1.54 in Group I and 5.12 in Group II, IL-2 was 0.05 in Group I and 0.02 in Group II, IL-4 was 0.018 in Group I and 0.0021 in Group II, IL-6 was 0.83 in Group I and 0.92 in Group II, MCP-1 was 64.5 in Group I and 23.1 in Group II, and TNF-alpha was 1.54 in Group I and 1.05 in Group II. There was a significant higher level of TNF-alpha in virus + patients ( < 0.05).
CONCLUSION
The cytokine level was increased in patients with peri-implantitis as compared to patients with healthy dental implants. Virus-positive patients exhibited higher cytokine levels than virus-negative patients.
背景
本研究旨在评估种植体周围炎患者和健康患者体内细胞因子及疱疹病毒的水平。
方法
纳入50例种植体健康的患者（I组）和患有种植体周围炎的患者（II组）。测定白细胞介素（IL）-1β、IL-2、IL-4、IL-6、单核细胞趋化蛋白-1（MCP-1）和肿瘤坏死因子-α（TNF-α）以及疱疹病毒的水平。
结果
I组IL-1β平均水平为1.54，II组为5.12；I组IL-2为0.05，II组为0.02；I组IL-4为0.018，II组为0.0021；I组IL-6为0.83，II组为0.92；I组MCP-1为64.5，II组为23.1；I组TNF-α为1.54，II组为1.05。病毒阳性患者的TNF-α水平显著更高（<0.05）。
结论
与种植体健康的患者相比，种植体周围炎患者的细胞因子水平升高。病毒阳性患者的细胞因子水平高于病毒阴性患者。
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