Department of Periodontics, School of Dentistry, University of Belgrade, Belgrade, Serbia.
Aust Dent J. 2011 Dec;56(4):382-8. doi: 10.1111/j.1834-7819.2011.01360.x. Epub 2011 Oct 3.
The purpose of this study was to estimate the prevalence of different genotypes of human cytomegalovirus (HCMV) and Epstein-Barr virus (EBV) in peri-implantitis and mucositis sites, and to evaluate the correlation between herpesvirus presence and clinical parameters.
A total of 80 dental implants (mean time of loading, 4.16 ± 1.8 years) were evaluated during the course of the study (30 peri-implantitis, 25 mucositis and 25 healthy peri-implant sites). The following clinical parameters were assessed: visible plaque index, bleeding on probing, suppuration and probing depth. A polymerase chain reaction (PCR) assay was used to identify the presence of different HCMV and EBV genotypes in peri-implant tissue plaque samples.
HCMV-2 was detected in 53.3% and EBV-1 in 46.6% of the 30 peri-implantitis sites evaluated. By contrast, HCMV-2 was not detected in healthy periodontal sites and EBV-1 was detected in one healthy site. A statistically significant correlation was found between the presence of HCMV-2 and EBV-1 genotypes and clinical parameters of peri-implantitis.
The results from the present study confirmed the high prevalence of HCMV-2 and EBV-1 in the peri-implant tissue plaque of peri-implantitis sites and suggests a possible active pathogenic role of the viruses in peri-implantitis.
本研究旨在评估不同基因型人类巨细胞病毒（HCMV）和 Epstein-Barr 病毒（EBV）在种植体周围炎和黏膜炎部位的流行情况，并评估疱疹病毒存在与临床参数之间的相关性。
本研究共评估了 80 个种植体（平均加载时间为 4.16±1.8 年）（30 个种植体周围炎、25 个黏膜炎和 25 个健康种植体部位）。评估了以下临床参数：可见菌斑指数、探诊出血、溢脓和探诊深度。聚合酶链反应（PCR）检测用于鉴定种植体组织斑块样本中不同 HCMV 和 EBV 基因型的存在。
在评估的 30 个种植体周围炎部位中，检测到 HCMV-2 为 53.3%，EBV-1 为 46.6%。相比之下，在健康牙周部位未检测到 HCMV-2，在一个健康部位检测到 EBV-1。HCMV-2 和 EBV-1 基因型的存在与种植体周围炎的临床参数之间存在统计学显著相关性。
本研究结果证实了 HCMV-2 和 EBV-1 在种植体周围炎部位种植体组织斑块中的高流行率，并提示病毒在种植体周围炎中可能具有积极的致病作用。
