Huang Zhengwei, Wu Linjing, Wang Wenhao, Zhou Yue, Zhang Xuejuan, Huang Ying, Pan Xin, Wu Chuanbin
College of Pharmacy, Jinan University, Guangzhou, 510006 People's Republic of China.
School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, 510006 People's Republic of China.
J Nanopart Res. 2021;24(1):10. doi: 10.1007/s11051-021-05384-1. Epub 2022 Jan 7.
Nano-systems (size range: 1 ~ 1000 nm) have been widely investigated as pulmonary drug delivery carriers, and the safety of inhaled nano-systems has aroused general interests. In this work, bibliometric analysis was performed to describe the current situation of related literature, figure out the revolutionary trends, and eventually forecast the possible future directions. The relevant articles and reviews from 2001 to 2020 were retrieved from the Web of Science Core Collection. The documents were processed by Clarivate Analytic associated with Web of Science database, Statistical Analysis Toolkit for Informetric, bibliometric online platform and VOSviewer, and the data were visualized. The bibliometric overview of the literature was described, citation analysis was performed, and research hotspots were showcased. The bibliometric analysis of 3362 documents of interest indicated that most of the relevant source titles were in the fields of toxicology, pharmacy, and materials science. The three research hotspots were the biological process of inhalable nano-systems in vivo, the manufacture of inhalable nano-systems, and the impact of nano-systems on human health in the environment. Toxicity and safety have always been the keywords. The USA was the major contributing country, and international collaboration and co-authorship were common phenomena. The general situation and development trend of literature of inhalable nano-systems were summarized. It was anticipated that bibliometrics analysis could provide new ideas for the future research of inhalable nano-systems.
The online version contains supplementary material available at 10.1007/s11051-021-05384-1.
纳米系统（尺寸范围：1至1000纳米）已被广泛研究作为肺部药物递送载体，吸入纳米系统的安全性引起了广泛关注。在这项工作中，进行了文献计量分析以描述相关文献的现状，找出变革趋势，并最终预测可能的未来方向。从科学网核心合集检索了2001年至2020年的相关文章和综述。这些文献由与科学网数据库相关联的科睿唯安分析、信息计量统计分析工具包、文献计量在线平台和VOSviewer进行处理，并对数据进行可视化。描述了文献的计量学概况，进行了引文分析，并展示了研究热点。对3362篇相关文献的计量分析表明，大多数相关来源标题属于毒理学、药学和材料科学领域。三个研究热点是可吸入纳米系统在体内的生物学过程、可吸入纳米系统的制造以及纳米系统在环境中对人类健康的影响。毒性和安全性一直是关键词。美国是主要贡献国家，国际合作和共同署名是常见现象。总结了可吸入纳米系统文献的概况和发展趋势。预计文献计量分析可为可吸入纳米系统的未来研究提供新思路。
在线版本包含可在10.1007/s11051-021-05384-1获取的补充材料。
