Institute of Urology, Lanzhou University Second Hospital, Key Laboratory of Gansu Province for Urological Diseases, Gansu Nephro-Urological Clinical Center, Lanzhou, China.
Clinical School of Cardiovascular Disease, Tianjin Medical University, Tianjin, China.
Nanomedicine (Lond). 2024;19(26):2139-2157. doi: 10.1080/17435889.2024.2391267. Epub 2024 Sep 3.
We conducted a bibliometric analysis to quantitatively study the development pathway, research hotspots and evolutionary trends of nano-drug delivery systems (NDDS) in treating urological tumors. We used the Web of Science Core Collection to retrieve the literature related to NDDS in the urological tumors up to November 1, 2023. Bibliometric analysis and visualization were conducted using CiteSpace, VOSviewer and R-Bibliometrix. The major aspects of analysis included contributions from different countries/regions, authors' contributions, keywords identification, citation frequencies and overall research trends. We included 3,220 articles. The analysis of annual publication trends revealed significant growth in this field since 2010, which has continued to the present day. The United States and China have far exceeded other countries/regions in the publication volume of papers in this field. The progression of the shell structure of NDDS in the urinary system has gradually transitioned from non-biological materials to biocompatible materials and ultimately to completely biocompatible materials. Mucoadhesive NDDS for intravesical drug delivery is a hotspot and a potential research material for bladder cancer. The field of NDDS in urological tumors has emerged as a research hotspot. Future research should focus on synergistic effects of NDDS with other treatment modalities.
我们进行了文献计量分析，以定量研究纳米药物递送系统（NDDS）在治疗泌尿系统肿瘤方面的发展途径、研究热点和演变趋势。我们使用 Web of Science 核心合集，检索了截至 2023 年 11 月 1 日与泌尿系统肿瘤中 NDDS 相关的文献。使用 CiteSpace、VOSviewer 和 R-Bibliometrix 进行文献计量分析和可视化。分析的主要方面包括不同国家/地区的贡献、作者的贡献、关键词识别、引用频率和整体研究趋势。我们共纳入了 3220 篇文章。年度发表趋势分析显示，自 2010 年以来，该领域的研究呈显著增长趋势，一直持续到今天。美国和中国在该领域的论文发表量远远超过其他国家/地区。NDDS 在泌尿系统中的壳结构的发展逐渐从非生物材料过渡到生物相容性材料，最终完全是生物相容性材料。用于膀胱内药物递送的黏附性 NDDS 是一个热点，也是膀胱癌的潜在研究材料。NDDS 在泌尿系统肿瘤中的研究领域已经成为一个研究热点。未来的研究应集中在 NDDS 与其他治疗方式的协同效应上。
