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小鼠单次注射MPTP后黑质中辅酶Q的短暂耗竭。

Transient nigral ubiquinone depletion after single MPTP administration in mice.

作者信息

Fariello R G, Ghirardi O, Peschechera A, Ramacci M T, Angelucci L

机构信息

Department of Neurology, Jefferson Medical College, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania 19107.

出版信息

Neuropharmacology. 1987 Dec;26(12):1799-802. doi: 10.1016/0028-3908(87)90137-7.

DOI:10.1016/0028-3908(87)90137-7
PMID:3501845
Abstract

The administration of a single injection of 30 mg/kg MPTP to mice produces at 1 hr, a transient significant decrease of the reduced ubiquinol Q10 in the substantia nigra that is normalized afterwards. This suggests a transient stress imposed by MPTP (or more likely MPP+) in the mitochondrial respiratory and/or oxidoreducing system, located in close proximity to the NADH system.

摘要

给小鼠单次注射30毫克/千克的MPTP后1小时，黑质中还原型泛醇Q10会出现短暂的显著下降，随后恢复正常。这表明MPTP（或更可能是MPP+）对位于NADH系统附近的线粒体呼吸和/或氧化还原系统施加了短暂的压力。

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Transient nigral ubiquinone depletion after single MPTP administration in mice.小鼠单次注射MPTP后黑质中辅酶Q的短暂耗竭。
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The histological effects of intracerebral injection or infusion of MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) and MPP+ (1-methyl-4-phenylpyridinium) in rat and mouse.脑内注射或输注MPTP（1-甲基-4-苯基-1,2,3,6-四氢吡啶）和MPP +（1-甲基-4-苯基吡啶鎓）对大鼠和小鼠的组织学影响。
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