State Key Laboratory of Organic-Inorganic Composites, Beijing Laboratory of Biomedical Materials, College of Materials Science and Engineering, Beijing University of Chemical Technology, 15 North Third Ring Road, Beijing, 100029, P. R. China.
Department of Chemistry and Nanoscience, Ewha Womans University, Seoul, 03760, Korea.
Adv Mater. 2022 Mar;34(11):e2109111. doi: 10.1002/adma.202109111. Epub 2022 Feb 6.
Theranostic systems that permit both diagnosis and treatment in vivo are highly appealing means by which to meet the demands of precision medicine. However, most such systems remain subject to issues related to complex molecular design and synthesis, potential toxicity, and possible photoactivity changes. Herein, a novel supramolecular theranostic strategy involving biomarker protein activation (BPA) and a host-guest strategy is proposed. To exemplify BPA, a facile "one-for-all" nanotheranostic agent for both albumin detection and cancer treatment is demonstrated, which utilizes a nanoparticulate heavy-atom-free BODIPY dye derivative (B4 NPs). The fluorescence and photoactivity of BODIPY dyes are completely suppressed by aggregation-induced self-quenching in the nanoparticulate state. However, a Balb/c nude mouse model is used to confirm that following the disassembly of injected B4 NPs, BODIPY specifically binds albumin in vivo, accompanied by significantly enhanced biocompatibility and photothermal conversion efficiency. More importantly, this supramolecular host-guest BPA strategy enables the resultant nanoplatform to act as a facile and efficient strategy for photodynamic and photothermal immunotherapy.
治疗诊断一体化系统兼具诊断和治疗的功能，是满足精准医疗需求的极具吸引力的手段。然而，大多数这样的系统仍然存在与复杂的分子设计和合成、潜在毒性以及可能的光活性变化相关的问题。在此，提出了一种涉及生物标志物蛋白激活（BPA）和主体-客体策略的新型超分子治疗策略。为了举例说明 BPA，展示了一种用于白蛋白检测和癌症治疗的简便“通用”纳米治疗剂，该治疗剂利用了一种纳米颗粒无重原子 BODIPY 染料衍生物（B4 NPs）。在纳米颗粒状态下，BODIPY 染料的荧光和光活性完全被聚集诱导的自猝灭所抑制。然而，使用 Balb/c 裸鼠模型证实，在注入的 B4 NPs 解体后，BODIPY 特异性地在体内结合白蛋白，同时显著提高了生物相容性和光热转换效率。更重要的是，这种超分子主体-客体 BPA 策略使所得纳米平台能够作为一种简便有效的光动力和光热免疫治疗策略。
