Programa de Pós-Graduação em Ciências Pneumológicas, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Fundação Hospitalar Getúlio Vargas, Sapucaia do Sul, RS, Brasil.
Serviço de Pneumologia, Hospital das Clínicas de Porto Alegre, Porto Alegre, RS, Brasil.
Braz J Med Biol Res. 2022 Jan 5;55:e11149. doi: 10.1590/1414-431X2021e11149. eCollection 2022.
More information is needed on asthma control and health-related quality of life (HRQoL) in smokers with severe asthma. The main study objective was to characterize the association of HRQoL and disease control with cigarette smoking in individuals with severe asthma. A secondary objective was to analyze subject characteristics according to asthma onset: asthma that developed before smoking initiation versus asthma that developed after smoking initiation. This cross-sectional study included subjects with severe asthma aged 18-65 years. HRQoL was assessed using the Asthma Quality of Life Questionnaire (AQLQ) and asthma control was assessed using the Asthma Control Test (ACT) and Global Initiative for Asthma (GINA) criteria. Of the 87 patients studied, 58 (66.7%) were classified as asthmatics who had never smoked and 29 (33.3%) as asthmatics with smoking exposure. The proportion of subjects with uncontrolled asthma was higher in the asthma and smoking group (GINA criteria: P=0.032 and ACT criteria: P=0.003. There were no between-group differences in overall AQLQ score (P=0.475) or AQLQ domain scores (P>0.05). Fifty-eight subjects (66.7%) were nonsmokers, 20 (23%) had asthma onset before smoking, and 9 (10.3%) had asthma onset after smoking. Asthma onset before smoking was associated with uncontrolled asthma (P=0.013). In subjects with severe asthma, smoking was associated with a higher rate of uncontrolled disease but not with HRQoL scores.
需要更多关于吸烟严重哮喘患者的哮喘控制和健康相关生活质量（HRQoL）的信息。主要研究目的是描述 HRQoL 和疾病控制与严重哮喘患者吸烟之间的关联。次要目的是根据哮喘发作分析受试者特征：在吸烟开始之前发生的哮喘与在吸烟开始之后发生的哮喘。这项横断面研究纳入了年龄在 18-65 岁之间的严重哮喘患者。使用哮喘生活质量问卷（AQLQ）评估 HRQoL，使用哮喘控制测试（ACT）和全球哮喘倡议（GINA）标准评估哮喘控制。在 87 名研究对象中，58 名（66.7%）被归类为从未吸烟的哮喘患者，29 名（33.3%）为有吸烟暴露的哮喘患者。在哮喘和吸烟组中，未控制哮喘的患者比例更高（GINA 标准：P=0.032，ACT 标准：P=0.003）。总体 AQLQ 评分（P=0.475）或 AQLQ 领域评分（P>0.05）在两组之间无差异。58 名受试者（66.7%）为非吸烟者，20 名（23%）有哮喘发作前吸烟，9 名（10.3%）有哮喘发作后吸烟。哮喘发作前吸烟与未控制哮喘有关（P=0.013）。在严重哮喘患者中，吸烟与更高的未控制疾病率相关，但与 HRQoL 评分无关。
