Huang Zixu, Nazifi Sina, Jafari Parham, Karim Alamgir, Ghasemi Hadi
Department of Mechanical Engineering, University of Houston, 4726 Calhoun Road, Houston, Texas 77204-4006, United States.
Department of Chemical and Biomolecular Engineering, University of Houston, 4726 Calhoun Road, Houston, Texas 77204-4006, United States.
ACS Appl Bio Mater. 2020 Feb 17;3(2):911-919. doi: 10.1021/acsabm.9b00982. Epub 2020 Jan 16.
Recently, intensive research has been conducted on the development of bacterial repelling surfaces because of the disadvantages of the conventional bactericidal leaching and contact-killing surfaces for practical application. Among these bacteria-repelling methodologies, zwitterionic polymers were widely investigated because of its excellent nonfouling properties, but its durability has limited its widespread use since most of the surfaces were developed by constructing polymer brushes via atom transfer radical polymerization (ATRP). In this study, we developed zwitterionic polymer surfaces with desirable mechanical and chemical durability for long-term use through simple blending of poly(sulfobetaine methacrylate) (PSBMA)/poly(ether sulfone) (PES) semi-interpenetrated networked microgels with hydrophobic PES polymer matrix. Results show that the as-prepared surfaces can efficiently induce hydration layers and, thus, reduce the bacterial attachment through resisting nonspecific protein adsorption. The bacterial adhesion for and was investigated under both flow and static conditions. This work has set a paradigm for developing durable antibacterial surfaces with nonfouling properties.
近年来，由于传统杀菌浸出和接触杀灭表面在实际应用中的缺点，人们对细菌排斥表面的开发进行了深入研究。在这些细菌排斥方法中，两性离子聚合物因其优异的抗污染性能而受到广泛研究，但其耐久性限制了其广泛应用，因为大多数表面是通过原子转移自由基聚合（ATRP）构建聚合物刷来开发的。在本研究中，我们通过将聚（甲基丙烯酸磺酸甜菜碱）（PSBMA）/聚（醚砜）（PES）半互穿网络微凝胶与疏水性PES聚合物基质简单混合，开发出了具有理想机械和化学耐久性的两性离子聚合物表面，可长期使用。结果表明，所制备的表面能够有效地诱导水化层，从而通过抵抗非特异性蛋白质吸附来减少细菌附着。在流动和静态条件下研究了大肠杆菌和金黄色葡萄球菌的细菌粘附情况。这项工作为开发具有抗污染性能的耐用抗菌表面树立了典范。
