Cai Luyao, Wei Jiao, Ma Danhua, Xu Hao, Qing Maofeng, Wang Zhen, Shen Yingqiang, Zhou Yu
State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.
Department of Oral Mucosal Diseases, State Key Laboratory of Military Stomatology and National Clinical Research Center for Oral Disease and Shaanxi Key Laboratory of Stomatology, School of Stomatology, The Fourth Military University, Xi'an, Shanxi, China.
J Dent Sci. 2022 Jan;17(1):476-481. doi: 10.1016/j.jds.2021.07.024. Epub 2021 Aug 18.
BACKGROUND/PURPOSE: Exfoliative cheilitis (EC) is a chronic and reversible inflammatory disease of the lips without definite etiology. Clinically, different types of allergens can be found in exfoliative cheilitis patients, however, few studies have focused on the relationship between exfoliative cheilitis and hypersensitivity. This research aimed to investigate the prevalence of hypersensitivity in EC patients.
A prospective study was conducted in 30 patients with exfoliative cheilitis and 30 healthy controls, matched in age and sex. Laboratory tests included serum total IgE, allergen-specific IgE, and food-specific IgG.
Increased serum total IgE level, positive food-specific IgG were seen more frequently in exfoliative cheilitis patients than in healthy control (P < 0.05). Special IgE level to FX5 and the degree of food-specific IgG to wheat were seen higher in exfoliative cheilitis patients than in healthy control (P < 0.05).
This study suggests that patients with exfoliative cheilitis may have predisposition of hypersensitivity. The detection of allergens should be strengthened in the future clinical work.
背景/目的：剥脱性唇炎（EC）是一种病因不明的慢性可逆性唇部炎症性疾病。临床上，剥脱性唇炎患者可发现不同类型的变应原，然而，很少有研究关注剥脱性唇炎与超敏反应之间的关系。本研究旨在调查剥脱性唇炎患者中超敏反应的患病率。
对30例剥脱性唇炎患者和30例年龄、性别相匹配的健康对照者进行了一项前瞻性研究。实验室检查包括血清总IgE、变应原特异性IgE和食物特异性IgG。
剥脱性唇炎患者血清总IgE水平升高、食物特异性IgG阳性的情况比健康对照者更常见（P<0.05）。剥脱性唇炎患者对FX5的特异性IgE水平和对小麦的食物特异性IgG程度高于健康对照者（P<0.05）。
本研究表明，剥脱性唇炎患者可能有超敏反应倾向。未来临床工作中应加强变应原检测。
