Ahmet'yanov M A, Reikhert L I, Kicherova O A, Deeva M V, Makarova D V
Tyumen State Medical University, Tyumen, Russia.
Zh Nevrol Psikhiatr Im S S Korsakova. 2021;121(12):119-122. doi: 10.17116/jnevro2021121121119.
Healthy sleep is necessary to ensure the stability of the body's homeostasis, the consistency of immunological reactions, the optimal functioning of internal organs, the nervous system, and cognitive functions. The patterns of changes in circadian rhythms have been studied in many diseases, however, SARS-CoV-2 infection is a new reality, and the basic mechanisms of the body's functioning in this pathology require in-depth study. Despite the complexity of analytical work in a pandemic, experience in diagnosing COVID-19 has already been accumulated, treatment algorithms have been developed in various clinical situations, and vaccines have been developed. The least studied issues are the long-term consequences of COVID-19. At the same time, there is every reason to believe that patients need long-term rehabilitation in the «postcovid period» of SARS-CoV-2, including due to damage to the nervous system. Analysis of publications, from descriptions of clinical cases to literature reviews, allows us to accumulate empirical experience, which will make it possible in the future to establish markers of prognosis of the disease for effective prevention of long-term consequences. The results of current prospective studies draw attention to the presence of dyssomnias and obstructive sleep apnea syndrome not only as a frequent consequence of the postponed coronavirus infection, but also as a factor that significantly worsens the prognosis in the acute period of the disease. It has been repeatedly established that sleep deprivation adversely affects the body's resistance, including to SARS-CoV-2, and requires adjustment to improve the prognosis in the acute and long-term periods of the disease in patients with COVID-19.
健康睡眠对于确保身体内环境稳定、免疫反应一致性、内脏器官、神经系统和认知功能的最佳运作至关重要。昼夜节律变化模式已在许多疾病中得到研究,然而,新型冠状病毒2(SARS-CoV-2)感染是一个新情况,身体在这种病理状态下的基本运作机制需要深入研究。尽管在大流行期间分析工作复杂,但已经积累了诊断新型冠状病毒肺炎(COVID-19)的经验,已制定了各种临床情况下的治疗算法,并且研发了疫苗。研究最少的问题是COVID-19的长期后果。同时,完全有理由相信,患者在SARS-CoV-2的“新冠后时期”需要长期康复,包括由于神经系统受损。对从临床病例描述到文献综述的出版物进行分析,使我们能够积累经验,这将有可能在未来确定疾病预后标志物,以有效预防长期后果。当前前瞻性研究结果提醒人们注意,失眠和阻塞性睡眠呼吸暂停综合征不仅是延迟的冠状病毒感染的常见后果,也是在疾病急性期显著恶化预后的一个因素。反复证实,睡眠剥夺会对身体抵抗力产生不利影响,包括对SARS-CoV-2的抵抗力,并且需要进行调整以改善COVID-19患者在疾病急性期和长期的预后。