Nomoto M, Thompson P D, Sheehy M P, Quinn N P, Marsden C D
University Department of Neurology, Institute of Psychiatry, Denmark Hill, London, England.
Mov Disord. 1987;2(1):53-6. doi: 10.1002/mds.870020107.
The occurrence of chorea, induced by trihexyphenidyl (benzhexol hydrochloride) during the treatment of five adult patients who had focal or segmental dystonia, is described. The dose at which chorea appeared ranged from 15 to 60 mg/day (mean 31.7 mg/day). All but one patient had developed common adverse effects of this drug (dry mouth, blurred vision, and confusion) at lower doses (mean 21.8 mg per day). There was an inverse relationship between the age of the patient and the dose of trihexyphenidyl at which chorea developed.
本文描述了在治疗5例患有局灶性或节段性肌张力障碍的成年患者时，由苯海索（盐酸苯海索）诱发的舞蹈症的发生情况。出现舞蹈症的剂量范围为15至60毫克/天（平均31.7毫克/天）。除1例患者外，所有患者在较低剂量（平均每天21.8毫克）时均出现了该药物的常见不良反应（口干、视力模糊和意识模糊）。患者年龄与出现舞蹈症时苯海索的剂量之间存在反比关系。
