Stomatological Center of Peking University Shenzhen Hospital, Guangdong Provincial High-level Clinical Key Specialty, Guangdong Province Engineering Research Center of Oral Disease Diagnosis and Treatment, Shenzhen, China.
Peking University Shenzhen Hospital, Clinical College of Anhui Medical University, Shenzhen, China.
Tissue Eng Part B Rev. 2023 Feb;29(1):62-77. doi: 10.1089/ten.TEB.2022.0065. Epub 2022 Oct 21.
Temporomandibular joint osteoarthritis (TMJOA) is a gradual degenerative jaw joint condition. Until recent years, TMJOA is still relatively unrecognized and ineffective to be treated. Appropriate animal models with reliable detection methods can help researchers understand the pathophysiology of TMJOA and find therapeutic options. In this study, we summarized common animal models of TMJOA created by chemical, surgical, mechanical, and genetical approaches. The relevant pathological symptoms and induction mechanisms were outlined. In addition, different pathological indicators, furthermore, emerging therapeutic regimens, such as intra-articular drug delivery and tissue engineering-based approaches to treat TMJOA based on these animal models, were summarized and updated. Understanding the physiology and pathogenesis of the TMJOA, together using various ways to diagnose the TMJOA, were elaborated, including imaging techniques, molecular techniques for detecting inflammatory cytokines, histochemical staining, and histomorphometry measures. A more reliable diagnosis will enable the development of new prevention and more effective treatment strategies and thereby improve the quality of life of TMJOA patients. Impact statement Temporomandibular joint osteoarthritis (TMJOA) affects 8 to 16 percent of the population worldwide. However, TMJOA is still relatively unrecognized and ineffective to be treated in the clinic. Appropriate animal models with reliable diagnostic methods can help researchers understand the pathophysiology of TMJOA and find therapeutic options. We herein summarized common animal models of TMJOA and various ways to diagnose the TMJOA. More importantly, emerging therapeutic regimens to treat TMJOA based on these animal models were summarized. With the aid of strategies listed, more effective treatment strategies will be developed and thereby improve the life quality of TMJOA patients.
颞下颌关节骨关节炎（TMJOA）是一种渐进性的下颌关节退行性疾病。直到近年来，TMJOA 仍然相对未被认识，治疗效果不佳。适当的动物模型和可靠的检测方法可以帮助研究人员了解 TMJOA 的病理生理学，并找到治疗选择。在本研究中，我们总结了通过化学、手术、机械和遗传方法创建的常见 TMJOA 动物模型。概述了相关的病理症状和诱导机制。此外，总结和更新了不同的病理指标，以及基于这些动物模型的新兴治疗方案，如关节内药物输送和组织工程方法治疗 TMJOA。了解 TMJOA 的生理学和发病机制，以及使用各种方法诊断 TMJOA，包括影像学技术、检测炎症细胞因子的分子技术、组织化学染色和组织形态计量学测量，都进行了阐述。更可靠的诊断将使新的预防和更有效的治疗策略得以发展，从而提高 TMJOA 患者的生活质量。
影响说明
颞下颌关节骨关节炎（TMJOA）影响全球 8%至 16%的人口。然而，TMJOA 在临床上仍然相对未被认识，治疗效果不佳。适当的动物模型和可靠的诊断方法可以帮助研究人员了解 TMJOA 的病理生理学，并找到治疗选择。我们在此总结了常见的 TMJOA 动物模型和诊断 TMJOA 的各种方法。更重要的是，总结了基于这些动物模型治疗 TMJOA 的新兴治疗方案。借助列出的策略，将开发出更有效的治疗策略，从而提高 TMJOA 患者的生活质量。
