Institute for Human Neuroscience, Boys Town National Research Hospital, Omaha, Nebraska, USA.
College of Medicine, University of Nebraska Medical Center (UNMC), Omaha, Nebraska, USA.
Hum Brain Mapp. 2023 Sep;44(13):4679-4691. doi: 10.1002/hbm.26409. Epub 2023 Jul 7.
The increasing incidence of age-related comorbidities in people with HIV (PWH) has led to accelerated aging theories. Functional neuroimaging research, including functional connectivity (FC) using resting-state functional magnetic resonance imaging (rs-fMRI), has identified neural aberrations related to HIV infection. Yet little is known about the relationship between aging and resting-state FC in PWH. This study included 86 virally suppressed PWH and 99 demographically matched controls spanning 22-72 years old who underwent rs-fMRI. The independent and interactive effects of HIV and aging on FC were investigated both within- and between-network using a 7-network atlas. The relationship between HIV-related cognitive deficits and FC was also examined. We also conducted network-based statistical analyses using a brain anatomical atlas (n = 512 regions) to ensure similar results across independent approaches. We found independent effects of age and HIV in between-network FC. The age-related increases in FC were widespread, while PWH displayed further increases above and beyond aging, particularly between-network FC of the default-mode and executive control networks. The results were overall similar using the regional approach. Since both HIV infection and aging are associated with independent increases in between-network FC, HIV infection may be associated with a reorganization of the major brain networks and their functional interactions in a manner similar to aging.
随着 HIV 感染者（PWH）年龄相关合并症的发病率不断上升，加速衰老理论应运而生。包括使用静息态功能磁共振成像（rs-fMRI）的功能连接（FC）在内的功能性神经影像学研究，已经确定了与 HIV 感染相关的神经异常。然而，人们对 PWH 衰老与静息态 FC 之间的关系知之甚少。本研究纳入了 86 名病毒抑制的 PWH 和 99 名年龄匹配的对照者，年龄在 22-72 岁之间，均接受了 rs-fMRI 检查。使用 7 个网络图谱，研究了 HIV 和衰老对 FC 的独立和交互影响。还检查了 HIV 相关认知缺陷与 FC 之间的关系。我们还使用大脑解剖图谱（n=512 个区域）进行了基于网络的统计分析，以确保在独立方法中得到相似的结果。我们发现，年龄和 HIV 在网络间 FC 方面存在独立影响。与年龄相关的 FC 增加是广泛存在的，而 PWH 则表现出超出衰老的进一步增加，特别是默认模式和执行控制网络之间的网络间 FC。使用区域方法的结果总体上相似。由于 HIV 感染和衰老均与网络间 FC 的独立增加有关，因此 HIV 感染可能与大脑主要网络及其功能相互作用的重新组织有关，其方式类似于衰老。
