Faculty of Sport and Health Sciences, University of Jyväskylä, Jyvaskylä, Finland.
Department of Neuroscience and Biomedical Engineering, Aalto University School of Science, Espoo, Finland.
J Neurophysiol. 2022 Feb 1;127(2):559-570. doi: 10.1152/jn.00267.2021. Epub 2022 Jan 19.
The Rolandic beta rhythm, at ∼20 Hz, is generated in the somatosensory and motor cortices and is modulated by motor activity and sensory stimuli, causing a short lasting suppression that is followed by a rebound of the beta rhythm. The rebound reflects inhibitory changes in the primary sensorimotor (SMI) cortex, and thus it has been used as a biomarker to follow the recovery of patients with acute stroke. The longitudinal stability of beta rhythm modulation is a prerequisite for its use in long-term follow-ups. We quantified the reproducibility of beta rhythm modulation in healthy subjects in a 1-year-longitudinal study both for MEG and EEG at , 1 month (, = 8) and 1 year (, = 19). The beta rhythm (13-25 Hz) was modulated by fixed tactile and proprioceptive stimulations of the index fingers. The relative peak strengths of beta suppression and rebound did not differ significantly between the sessions, and intersession reproducibility was good or excellent according to intraclass correlation-coefficient values (0.70-0.96) both in MEG and EEG. Our results indicate that the beta rhythm modulation to tactile and proprioceptive stimulation is well reproducible within 1 year. These results support the use of beta modulation as a biomarker in long-term follow-up studies, e.g., to quantify the functional state of the SMI cortex during rehabilitation and drug interventions in various neurological impairments. The present study demonstrates that beta rhythm modulation is highly reproducible in a group of healthy subjects within a year. Hence, it can be reliably used as a biomarker in longitudinal follow-up studies in different neurological patient groups to reflect changes in the functional state of the sensorimotor cortex.
罗伦氏贝塔节律，约 20 Hz，产生于躯体感觉和运动皮质，受运动活动和感觉刺激调制，引起短暂的抑制，随后贝塔节律反弹。反弹反映了初级感觉运动（SMI）皮质中的抑制性变化，因此它被用作跟踪急性中风患者康复的生物标志物。贝塔节律调制的纵向稳定性是其在长期随访中使用的前提。我们在为期 1 年的纵向研究中量化了健康受试者中 MEG 和 EEG 中贝塔节律调制的可重复性，时间分别为 、 （n = 8）和 （n = 19）。贝塔节律（13-25 Hz）通过固定的食指触觉和本体感觉刺激进行调制。β 抑制和反弹的相对峰值强度在各次测试之间没有显著差异，根据组内相关系数值（0.70-0.96），各次测试之间的可重复性良好或优秀，在 MEG 和 EEG 中均如此。我们的结果表明，在 1 年内，对触觉和本体感觉刺激的贝塔节律调制具有良好的可重复性。这些结果支持将β调制用作长期随访研究中的生物标志物，例如，在各种神经损伤中量化 SMI 皮质的功能状态，以评估康复和药物干预的效果。本研究表明，在健康受试者中，贝塔节律调制在一年内具有高度可重复性。因此，它可以可靠地用于不同神经患者群体的纵向随访研究中，以反映感觉运动皮质功能状态的变化。
