Bolzan Juliana Aparecida, Lino de Oliveira Cilene
Departamento de Ciências Fisiológica, Universidade Federal de Santa Catarina, Florianópolis, Santa Catarina, Brazil.
Pós-Graduação em Farmacologia, Universidade Federal de Santa Catarina, Florianopolis, SC, Brazil.
BMJ Open Sci. 2021 Mar 4;5(1):e100077. doi: 10.1136/bmjos-2020-100077. eCollection 2021.
Studies in rodents associated the deficits of adult hippocampal neurogenesis with behavioural anomalies which may be reversed by antidepressant treatments. A previous systematic review (SR) and meta-analysis (MA) indicated a hierarchy within the proneurogenic effects of different antidepressants in naive rodents. The present review aims to evaluate a more comprehensive sample of studies investigating the links between the effects of different antidepressants and adult hippocampal neurogenesis.
Protocols were planned following Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols guidelines. Searches in Embase, Medline, Scopus and Web of Science followed by screening with inclusion/exclusion criteria will provide relevant publications. First SR will summarise the effects of antidepressants on adult hippocampal neurogenesis on different laboratory rodents. Second SR will summarise the correlations between neurogenic and behavioural effects of antidepressants while the third will focus on cause-effect relationships between them. If feasible, data will be analysed by pairwise or network random-effect or multivariate MA to determine the direction, magnitude, significance and heterogeneity (I) of the estimated effect sizes on global or subgroup levels. Funnel plotting, Egger regression, 'trim and fill' will be used to estimate the risk of publication bias. Quality assessment of the included publications will be performed by applying adapted CAMARADES, Syrcles' risk of bias or CINeMA tools.
Find a preliminary version of this protocol at the Open Science Framework (https://osf.io/gmsvd/). Data extraction has already started. Results shall be published in a peer-reviewed journal. Due to the continuous production in the field, the implementation of a 'living SR' is intended.
对啮齿动物的研究表明，成年海马神经发生缺陷与行为异常有关，而抗抑郁治疗可能会逆转这种异常。先前的一项系统评价（SR）和荟萃分析（MA）表明，在未用药的啮齿动物中，不同抗抑郁药的促神经生成作用存在层级差异。本综述旨在评估更全面的研究样本，以调查不同抗抑郁药的作用与成年海马神经发生之间的联系。
检索策略、筛选、注释、数据管理：按照系统评价和荟萃分析方案的首选报告项目指南制定方案。在Embase、Medline、Scopus和Web of Science中进行检索，然后根据纳入/排除标准进行筛选，以提供相关出版物。第一项系统评价将总结抗抑郁药对不同实验啮齿动物成年海马神经发生的影响。第二项系统评价将总结抗抑郁药的神经生成作用与行为作用之间的相关性，而第三项将关注它们之间的因果关系。如果可行，将通过成对或网络随机效应或多变量荟萃分析对数据进行分析，以确定全球或亚组水平上估计效应大小的方向、大小、显著性和异质性（I）。将使用漏斗图、Egger回归、“修剪和填充”来估计发表偏倚的风险。将应用改编后的CAMARADES、Syrcles偏倚风险或CINeMA工具对纳入出版物进行质量评估。
在开放科学框架（https://osf.io/gmsvd/）上查找本方案的初步版本。数据提取已经开始。结果将发表在同行评审期刊上。由于该领域的研究不断进行，计划实施“动态系统评价”。
