Department of Medicine, Icahn School of Medicine at Mount Sinai, Mount Sinai Beth Israel, New York, New York, USA.
Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
Geriatr Gerontol Int. 2022 Mar;22(3):246-250. doi: 10.1111/ggi.14348. Epub 2022 Jan 20.
Despite the increasing attention that has been paid to amyloidosis in recent years, there have been few reports on amyloidosis mortality and its trends worldwide. This study aimed to evaluate the trends in crude and age-adjusted amyloidosis-associated mortality rates in Japan from 1998 to 2019.
We used national Vital Statistics data among older adults aged over 50 years. The data were analyzed using the joinpoint regression program to estimate the long-term trends and average annual percentage changes (AAPCs).
A total of 9158 amyloidosis-associated deaths were recorded from 1998 to 2019, of which 56.1% were in men. The crude mortality rate per 1 000 000 older adults aged over 80 years increased from 9.65 to 54.3 among men and from 7.02 to 22.1 among women during the study period. Overall, the AAPCs of age-adjusted amyloidosis-associated mortality rates increased significantly over the study period (1.8%, 95% confidence interval [CI], 1.0-2.7%). While the annual percentage change (APC) of age-adjusted mortality rates in women showed no significant change over the study period, the APC in men markedly increased in the 2013-2019 period (8.2%, 95% CI: 6.0-10.4%).
This study revealed an increasing trend in mortality associated with amyloidosis, and in particular a marked increase in mortality among men over the past 6 years. Considering its high mortality rate and susceptibility to the effects of an increasing population of older adults, amyloidosis deserves more attention from healthcare providers to improve the understanding of diagnosis, clinical treatment, and healthcare planning. Geriatr Gerontol Int 2022; 22: 246-250.
尽管近年来人们对淀粉样变性的关注度不断提高，但全球关于淀粉样变性死亡率及其趋势的报道甚少。本研究旨在评估日本 1998 年至 2019 年期间年龄标准化淀粉样变性相关性死亡率的变化趋势。
我们使用了年龄在 50 岁以上的老年人国家生命统计数据。使用 joinpoint 回归程序对数据进行分析，以估计长期趋势和平均年百分比变化（AAPC）。
1998 年至 2019 年期间共记录到 9158 例淀粉样变性相关性死亡，其中 56.1%为男性。在研究期间，年龄标准化的淀粉样变性相关性死亡率每 100 万 80 岁以上老年人的粗死亡率从男性的 9.65 升至 54.3，从女性的 7.02 升至 22.1。总体而言，研究期间年龄标准化的淀粉样变性相关性死亡率的 AAPC 呈显著上升趋势（1.8%，95%置信区间[CI]：1.0-2.7%）。尽管女性的年龄标准化死亡率的年百分比变化（APC）在研究期间无显著变化，但男性的 APC 在 2013-2019 年期间明显增加（8.2%，95%CI：6.0-10.4%）。
本研究揭示了淀粉样变性相关性死亡率呈上升趋势，尤其是过去 6 年来男性死亡率显著增加。鉴于其高死亡率和受老年人口增加影响的易感性，淀粉样变性值得医疗保健提供者给予更多关注，以提高对诊断、临床治疗和医疗保健规划的认识。老年医学与老年病学杂志 2022；22：246-250。
