Higashionna Tsukasa, Harada Keisaku, Maruo Akinari, Niimura Takahiro, Tan Elizabeth, Vu Quynh Thi, Kawabata Takayoshi, Ushio Soichiro, Hamano Hirofumi, Kajizono Makoto, Zamami Yoshito, Ishizawa Keisuke, Harada Ko, Hinotsu Shiro, Kano Mitsunobu R, Hagiya Hideharu, Koyama Toshihiro
Department of Pharmaceutical Biomedicine, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University, Okayama 7008558, Japan.
Department of Pharmacy, Okayama University Hospital, Okayama 7008558, Japan.
Cancers (Basel). 2023 Jul 26;15(15):3786. doi: 10.3390/cancers15153786.
Globally, the numbers of head and neck cancer (HNC) cases and related deaths have recently increased. In Japan, few studies have examined crude or age-adjusted HNC mortality rates. Therefore, this study aimed to determine the trends in crude and age-adjusted mortality rates for HNC per million individuals in Japan from 1999 to 2019. Data on HNC-associated deaths were extracted from the national death certificate database using the ( = 156,742). HNC mortality trends were analysed using joinpoint regression models to estimate annual percentage change (APC) and average APC (AAPC). Among men, no significant change was observed in the age-adjusted death rate trend from 1999 to 2014; however, a marked decrease was observed from 2014 to 2019. No changing point was observed in women. Age-adjusted mortality rates continuously decreased over the 21-year period, with an AAPC of -0.7% in men and -0.6% in women. In conclusion, the overall trend in age-adjusted rates of HNC-associated deaths decreased, particularly among men, in the past 5 years. These results will contribute to the formulation of medical policies to develop targeted screening and prevention programmes for HNC in Japan and determine the direction of treatment strategies.
在全球范围内，头颈癌（HNC）病例数和相关死亡人数最近有所增加。在日本，很少有研究调查过粗死亡率或年龄调整后的头颈癌死亡率。因此，本研究旨在确定1999年至2019年期间日本每百万人中头颈癌的粗死亡率和年龄调整后死亡率的趋势。使用（ = 156,742）从国家死亡证明数据库中提取与头颈癌相关的死亡数据。使用连接点回归模型分析头颈癌死亡率趋势，以估计年度百分比变化（APC）和平均APC（AAPC）。在男性中，1999年至2014年期间年龄调整后的死亡率趋势未观察到显著变化；然而，2014年至2019年期间观察到显著下降。女性未观察到变化点。在21年期间，年龄调整后的死亡率持续下降，男性的AAPC为-0.7%，女性为-0.6%。总之，在过去5年中，头颈癌相关死亡的年龄调整率总体呈下降趋势，尤其是在男性中。这些结果将有助于制定医疗政策，以制定日本头颈癌的针对性筛查和预防计划，并确定治疗策略的方向。
