Department of Microbiology, Molecular Genetics and Immunology, University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160, USA.
Laboratory of Microbiology Signals and Microenvironment, University of Rouen, 76821 Mont Saint Aignan, France.
Cells. 2022 Jan 17;11(2):302. doi: 10.3390/cells11020302.
The novel coronavirus SARS-CoV-2 has caused a pandemic resulting in millions of deaths worldwide. While multiple vaccines have been developed, insufficient vaccination combined with adaptive mutations create uncertainty for the future. Here, we discuss novel strategies to control COVID-19 relying on Defective Interfering Particles (DIPs) and related particles that arise naturally during an infection. Our intention is to encourage and to provide the basis for the implementation of such strategies by multi-disciplinary teams. We therefore provide an overview of SARS-CoV-2 for a multi-disciplinary readership that is specifically tailored to these strategies, we identify potential targets based on the current knowledge of the properties and functions of coronaviruses, and we propose specific strategies to engineer DIPs and other interfering or therapeutic nanoparticles.
新型冠状病毒 SARS-CoV-2 引发的大流行导致了全球数百万人死亡。虽然已经开发出多种疫苗，但疫苗接种不足加上适应性突变给未来带来了不确定性。在这里，我们讨论了依赖缺陷干扰颗粒 (DIP) 和感染过程中自然产生的相关颗粒来控制 COVID-19 的新策略。我们的目的是鼓励多学科团队实施这些策略，并为其提供基础。因此，我们为多学科读者提供了对 SARS-CoV-2 的概述，该概述专门针对这些策略进行了定制，我们根据冠状病毒的特性和功能的现有知识确定了潜在的目标，并提出了工程 DIP 及其他干扰或治疗性纳米颗粒的具体策略。
