Pediatrics Department, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Division of Biomedical Sciences, University of California Riverside, Riverside, CA 92521, USA.
Int J Mol Sci. 2022 Jan 9;23(2):708. doi: 10.3390/ijms23020708.
Omega-3 and omega-6 fatty acids are important for neonatal development and health. One mechanism by which omega-3 and omega-6 fatty acids exert their effects is through their metabolism into oxylipins and specialized pro-resolving mediators. However, the influence of oxylipins on fetal growth is not well understood. Therefore, the objective of this study was to identify oxylipins present in maternal and umbilical cord plasma and investigate their relationship with infant growth. Liquid chromatography-tandem mass spectrometry was used to quantify oxylipin levels in plasma collected at the time of delivery. Spearman's correlations highlighted significant correlations between metabolite levels and infant growth. They were then adjusted for maternal obesity (normal body mass index (BMI: ≤30 kg/m) vs. obese BMI (>30 kg/m) and smoking status (never vs. current/former smoker) using linear regression modeling. A -value < 0.05 was considered statistically significant. Our study demonstrated a diverse panel of oxylipins from the lipoxygenase pathway present at the time of delivery. In addition, both omega-3 and omega-6 oxylipins demonstrated potential influences on the birth length and weight percentiles. The oxylipins present during pregnancy may influence fetal growth and development, suggesting potential metabolites to be used as biomarkers for infant outcomes.
ω-3 和 ω-6 脂肪酸对新生儿的发育和健康很重要。ω-3 和 ω-6 脂肪酸发挥作用的一个机制是通过将其代谢为氧化脂质和专门的促解决介质。然而，氧化脂质对胎儿生长的影响还不是很清楚。因此，本研究的目的是鉴定母体和脐带血浆中存在的氧化脂质，并研究它们与婴儿生长的关系。在分娩时采集的血浆中使用液相色谱-串联质谱法来定量氧化脂质的水平。Spearman 相关性强调了代谢物水平与婴儿生长之间的显著相关性。然后，使用线性回归模型，根据母亲的肥胖状况（正常体重指数（BMI：≤30 kg/m）与肥胖 BMI（>30 kg/m）和吸烟状况（从不吸烟与当前/曾经吸烟）进行调整。A 值<0.05 被认为具有统计学意义。我们的研究表明，在分娩时存在多种来自脂氧合酶途径的氧化脂质。此外，ω-3 和 ω-6 氧化脂质都对出生长度和体重百分位有潜在影响。怀孕期间存在的氧化脂质可能会影响胎儿的生长和发育，这表明潜在的代谢物可用作婴儿结局的生物标志物。
