• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

基于mA调控因子的食管癌治疗分子亚型及潜在小分子药物的鉴定

Identification of Molecular Subtypes and Potential Small-Molecule Drugs for Esophagus Cancer Treatment Based on mA Regulators.

作者信息

Li Jianjun, Zhu Hongbo, Yang Qiao, Xiao Hua, Wu Haibiao, Fang Zhe, Li Wenjun, Cai Manbo

机构信息

Department of Oncology Radiotherapy, The First Affiliated Hospital, Hengyang Medical School, University of South China, No. 69 Chuanshan Road, Hengyang, Hunan, China.

出版信息

J Oncol. 2022 Jan 13;2022:5490461. doi: 10.1155/2022/5490461. eCollection 2022.

DOI:10.1155/2022/5490461
PMID:35069736
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8776445/
Abstract

BACKGROUND

Esophagus cancer (ESCA) is the sixth most frequent cancer in males, with 5-year overall survival of 15%-25%. RNA modifications function critically in cancer progression, and mA regulators are associated with ESCA prognosis. This study further revealed correlations between mA and ESCA development.

METHODS

Univariate Cox regression analysis and consensus clustering were applied to determine molecular subtypes. Functional pathways and gene ontology terms were enriched by gene set enrichment analysis. Protein-protein interaction (PPI) analysis on differentially expressed genes (DEGs) was conducted for hub gene screening. Public drug databases were employed to study the interactions between hub genes and small molecules.

RESULTS

Three molecular subtypes related to ESCA prognosis were determined. Based on multiple analyses among molecular subtypes, 146 DEGs were screened, and a PPT network of 15 hub genes was visualized. Finally, 8 potential small-molecule drugs (BMS-754807, gefitinib, neratinib, zuclopenthixol, puromycin, sulfasalazine, and imatinib) were identified for treating ESCA.

CONCLUSIONS

This study applied a new approach to analyzing the relation between mA and ESCA prognosis, providing a reference for exploring potential targets and drugs for ESCA treatment.

摘要

背景

食管癌（ESCA）是男性中第六大常见癌症，5年总生存率为15%-25%。RNA修饰在癌症进展中起关键作用，且mA调节因子与ESCA预后相关。本研究进一步揭示了mA与ESCA发生之间的相关性。

方法

应用单因素Cox回归分析和一致性聚类来确定分子亚型。通过基因集富集分析来富集功能通路和基因本体术语。对差异表达基因（DEGs）进行蛋白质-蛋白质相互作用（PPI）分析以筛选枢纽基因。利用公共药物数据库研究枢纽基因与小分子之间的相互作用。

结果

确定了三种与ESCA预后相关的分子亚型。基于分子亚型间的多项分析，筛选出146个DEGs，并构建了一个包含15个枢纽基因的PPI网络。最终，鉴定出8种潜在的小分子药物（BMS-754807、吉非替尼、奈拉替尼、氯普噻吨、嘌呤霉素、柳氮磺胺吡啶和伊马替尼）用于治疗ESCA。

结论

本研究应用了一种新方法来分析mA与ESCA预后之间的关系，为探索ESCA治疗的潜在靶点和药物提供了参考。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef9a/8776445/ee31fd7eb21b/JO2022-5490461.009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef9a/8776445/866cfded5839/JO2022-5490461.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef9a/8776445/a7e65d27cb0f/JO2022-5490461.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef9a/8776445/1dc39476f4b8/JO2022-5490461.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef9a/8776445/09c6cb8835b0/JO2022-5490461.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef9a/8776445/56344afcfc31/JO2022-5490461.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef9a/8776445/3b919a5e67f4/JO2022-5490461.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef9a/8776445/8d95495bcb6b/JO2022-5490461.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef9a/8776445/a3e1f74baa14/JO2022-5490461.008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef9a/8776445/ee31fd7eb21b/JO2022-5490461.009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef9a/8776445/866cfded5839/JO2022-5490461.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef9a/8776445/a7e65d27cb0f/JO2022-5490461.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef9a/8776445/1dc39476f4b8/JO2022-5490461.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef9a/8776445/09c6cb8835b0/JO2022-5490461.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef9a/8776445/56344afcfc31/JO2022-5490461.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef9a/8776445/3b919a5e67f4/JO2022-5490461.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef9a/8776445/8d95495bcb6b/JO2022-5490461.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef9a/8776445/a3e1f74baa14/JO2022-5490461.008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef9a/8776445/ee31fd7eb21b/JO2022-5490461.009.jpg

相似文献

1
Identification of Molecular Subtypes and Potential Small-Molecule Drugs for Esophagus Cancer Treatment Based on mA Regulators.基于mA调控因子的食管癌治疗分子亚型及潜在小分子药物的鉴定
J Oncol. 2022 Jan 13;2022:5490461. doi: 10.1155/2022/5490461. eCollection 2022.
2
Identification of cuproptosis-related subtypes, construction of a prognosis model, and tumor microenvironment landscape in gastric cancer.鉴定胃癌中与铜死亡相关的亚型，构建预后模型和肿瘤微环境景观。
Front Immunol. 2022 Nov 21;13:1056932. doi: 10.3389/fimmu.2022.1056932. eCollection 2022.
3
Screening and verification of potential gene targets in esophageal carcinoma by bioinformatics analysis and immunohistochemistry.通过生物信息学分析和免疫组织化学对食管癌潜在基因靶点进行筛选与验证
Ann Transl Med. 2022 Jan;10(2):70. doi: 10.21037/atm-21-6589.
4
Novel drug candidates for treating esophageal carcinoma: A study on differentially expressed genes, using connectivity mapping and molecular docking.用于治疗食管癌的新型候选药物：一项利用连通性图谱和分子对接对差异表达基因的研究
Int J Oncol. 2019 Jan;54(1):152-166. doi: 10.3892/ijo.2018.4618. Epub 2018 Nov 2.
5
Weighted Gene Correlation Network Analysis Identifies Specific Functional Modules and Genes in Esophageal Cancer.加权基因共表达网络分析鉴定食管癌中的特定功能模块和基因。
J Oncol. 2021 Dec 27;2021:8223263. doi: 10.1155/2021/8223263. eCollection 2021.
6
Identification of crucial genes correlated with esophageal cancer by integrated high-throughput data analysis.通过整合高通量数据分析鉴定与食管癌相关的关键基因
Medicine (Baltimore). 2020 May;99(20):e20340. doi: 10.1097/MD.0000000000020340.
7
Identification of prognostic biomarkers for breast cancer brain metastases based on the bioinformatics analysis.基于生物信息学分析的乳腺癌脑转移预后生物标志物的鉴定
Biochem Biophys Rep. 2022 Jan 10;29:101203. doi: 10.1016/j.bbrep.2022.101203. eCollection 2022 Mar.
8
Identification of clinical prognostic features of esophageal cancer based on m6A regulators.基于 m6A 调节因子鉴定食管癌的临床预后特征。
Front Immunol. 2022 Sep 8;13:950365. doi: 10.3389/fimmu.2022.950365. eCollection 2022.
9
Integrated bioinformatics analysis for the screening of hub genes and therapeutic drugs in ovarian cancer.卵巢癌中枢纽基因和治疗药物的筛选的综合生物信息学分析。
J Ovarian Res. 2020 Jan 27;13(1):10. doi: 10.1186/s13048-020-0613-2.
10
Prognostic Values and Underlying Regulatory Network of Cohesin Subunits in Esophageal Carcinoma.食管癌中黏连蛋白亚基的预后价值及潜在调控网络
J Cancer. 2022 Mar 6;13(5):1588-1602. doi: 10.7150/jca.66949. eCollection 2022.

引用本文的文献

1
Development and verification of a newly established cuproptosis-associated lncRNA model for predicting overall survival in uterine corpus endometrial carcinoma.一种新建立的用于预测子宫体子宫内膜癌总生存期的铜死亡相关长链非编码RNA模型的开发与验证
Transl Cancer Res. 2023 Aug 31;12(8):1963-1979. doi: 10.21037/tcr-23-61. Epub 2023 Aug 28.
2
Role of N6-Methyladenosine Methylation Regulators in the Drug Therapy of Digestive System Tumours.N6-甲基腺苷甲基化调节剂在消化系统肿瘤药物治疗中的作用
Front Pharmacol. 2022 Jun 9;13:908079. doi: 10.3389/fphar.2022.908079. eCollection 2022.

本文引用的文献

1
Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries.《全球癌症统计数据 2020：全球 185 个国家和地区 36 种癌症的发病率和死亡率估计》。
CA Cancer J Clin. 2021 May;71(3):209-249. doi: 10.3322/caac.21660. Epub 2021 Feb 4.
2
Characteristics and prognosis of jejunoileal gastrointestinal stromal tumours (GISTs) in the era of imatinib: a comparative study with gastric GISTs.在伊马替尼时代的空肠回肠胃肠道间质瘤（GISTs）的特征和预后：与胃 GISTs 的对比研究。
Clin Transl Oncol. 2021 Jul;23(7):1368-1376. doi: 10.1007/s12094-020-02528-y. Epub 2021 Jan 30.
3
Integration of the Drug-Gene Interaction Database (DGIdb 4.0) with open crowdsource efforts.
整合药物-基因相互作用数据库（DGIdb 4.0）与开放众包工作。
Nucleic Acids Res. 2021 Jan 8;49(D1):D1144-D1151. doi: 10.1093/nar/gkaa1084.
4
mA Reader HNRNPA2B1 Promotes Esophageal Cancer Progression via Up-Regulation of ACLY and ACC1.毫安阅读器HNRNPA2B1通过上调ACLY和ACC1促进食管癌进展。
Front Oncol. 2020 Sep 29;10:553045. doi: 10.3389/fonc.2020.553045. eCollection 2020.
5
Construction and Validation of an m6A RNA Methylation Regulators-Based Prognostic Signature for Esophageal Cancer.基于m6A RNA甲基化调节因子的食管癌预后标志物的构建与验证
Cancer Manag Res. 2020 Jul 6;12:5385-5394. doi: 10.2147/CMAR.S254870. eCollection 2020.
6
m A demethylase ALKBH5 promotes proliferation of esophageal squamous cell carcinoma associated with poor prognosis.去甲基酶 ALKBH5 促进食管鳞状细胞癌的增殖，与预后不良相关。
Genes Cells. 2020 Aug;25(8):547-561. doi: 10.1111/gtc.12792. Epub 2020 Jul 1.
7
SERPINE2 promotes esophageal squamous cell carcinoma metastasis by activating BMP4.丝氨酸蛋白酶抑制剂 2 通过激活骨形态发生蛋白 4 促进食管鳞癌细胞转移。
Cancer Lett. 2020 Jan 28;469:390-398. doi: 10.1016/j.canlet.2019.11.011. Epub 2019 Nov 12.
8
Cytoscape Automation: empowering workflow-based network analysis.Cytoscape 自动化：赋能基于工作流的网络分析。
Genome Biol. 2019 Sep 2;20(1):185. doi: 10.1186/s13059-019-1758-4.
9
The role of mA RNA methylation in human cancer.mRNA 甲基化在人类癌症中的作用。
Mol Cancer. 2019 May 29;18(1):103. doi: 10.1186/s12943-019-1033-z.
10
The Critical Role of RNA mA Methylation in Cancer.RNA mA 甲基化在癌症中的关键作用。
Cancer Res. 2019 Apr 1;79(7):1285-1292. doi: 10.1158/0008-5472.CAN-18-2965. Epub 2019 Mar 20.