Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Department of Paediatrics, Orebro University Hospital, Orebro, Sweden.
Acta Paediatr. 2022 May;111(5):1023-1026. doi: 10.1111/apa.16276. Epub 2022 Feb 10.
Most children with COVID-19 have mild symptoms, but data on the Omicron variant are rare. This paper describes unexpected cases with convulsions during 1 week in January 2022.
Four children with COVID-19 were admitted with convulsions to the paediatric department in Örebro, Sweden, when Omicron accounted for more than 98% of the country's COVID-19 cases. Three children tested positive for the virus, and one had clinical COVID-19. I was able to contact the parents of three boys, who gave consent for these case studies.
Two boys aged 3 and 21 months tested positive for the virus and a 14-year-old boy tested negative, but had a cold and family members who had tested positive. The teenager had a history of urinary tract infections, but the younger boys had no earlier comorbidities. None had a history of epilepsy or febrile convulsions. The younger children had a fever and the teenager had upper respiratory symptoms. The 3-month-old child had repeated convulsions for several hours, the 21-month-old had continuous convulsions for 15-20 min, and the teenager had a convulsion for 30-60 s, followed by uncharacteristic aggression.
Convulsions may be a sign of the Omicron variant in children with COVID-19.
大多数儿童感染 COVID-19 后症状较轻，但有关奥密克戎变异株的数据很少。本文描述了 2022 年 1 月的一周内，4 例 COVID-19 患儿出现惊厥的意外病例。
在瑞典厄勒布鲁，当 Omicron 变异株占该国 COVID-19 病例的 98%以上时，4 例 COVID-19 患儿因惊厥而被收入儿科病房。其中 3 例患儿病毒检测呈阳性，1 例患儿有临床 COVID-19 症状。我联系了 3 名男孩的父母，他们同意进行这些病例研究。
2 名 3 月龄和 21 月龄的男孩病毒检测呈阳性，1 名 14 岁的男孩病毒检测呈阴性，但有感冒症状，且其家庭成员检测呈阳性。该青少年有尿路感染史，但年龄较小的男孩此前无合并症。他们均无癫痫或热性惊厥史。年龄较小的儿童有发热，青少年有上呼吸道症状。3 月龄的儿童反复惊厥数小时，21 月龄的儿童持续惊厥 15-20 分钟，青少年惊厥 30-60 秒，随后出现异常攻击行为。
惊厥可能是 COVID-19 患儿感染奥密克戎变异株的一个征象。
