公众是否知道一场科学争议何时结束？2020 年 4 月至 2021 年 6 月期间法国公众对羟氯喹的看法。

Does the public know when a scientific controversy is over? Public perceptions of hydroxychloroquine in France between April 2020 and June 2021.

机构信息

Université de Paris, IRD, Inserm, CEPED (UMR 196), 75006 Paris, France; Aix Marseille Univ, INSERM, IRD, SESSTIM, Sciences Economiques & Sociales de la Santé & Traitement de l'Information Médicale, ISSPAM, Equipe CANBIOS Labellisée Ligue Contre le Cancer, 13005 Marseille, France.

Université de Paris, IRD, Inserm, CEPED (UMR 196), 75006 Paris, France; Institut COVID-19 Add Memoriam, université de Paris, 75006 Paris, France; WHO Collaborative Center for Research on Health and Humanitarian Policies and Practices, IRD, université de Paris, 75006 Paris, France; Columbia University, Mailman School of Public Health, New York, NY, USA.

出版信息

Therapie. 2022 Sep-Oct;77(5):591-602. doi: 10.1016/j.therap.2022.01.008. Epub 2022 Jan 17.

DOI:10.1016/j.therap.2022.01.008

PMID:35101281

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8801974/

Abstract

OBJECTIVES

In the early stages of the coronavirus disease 2019 (COVID-19) pandemic, chloroquine and its derivatives such as hydroxychloroquine (HCQ) were widely commented upon both within the scientific community and in the media. This paper explores the different factors that influenced public perceptions in France of the efficacy of HCQ as well as their evolution between April 2020 and June 2021.

METHODS

This article draws on 5 surveys conducted among representative samples of the French population (projects COCONEL and TRACTRUST; quota method, n=1006; 1004; 2006; 1014 and 1005). We asked questions on the effectiveness of chloroquine against COVID-19. We also collected sociodemographic variables and attitudes toward politics and science.

RESULTS

Between April and June 2021, the proportion of respondents who believed in the efficacy of HCQ decreased rapidly from 35% to 14%. The proportion of respondents who believed that HCQ is ineffective rose gradually from 6% to 21%. After adjusting for the temporal effect, the logistic regression showed a very strong association between political orientation and the belief in the efficacy of HCQ. Respondents who felt closest to the more radical parties (far-right and far-left) were more likely to believe in the efficacy of HCQ than those who felt closest to the political center (O.R. 2.48 [1.95-3.15] and 1.87 [1.44-2.43]). The role of trust in the government and in science and of the degree of political engagement were investigated in the two waves conducted after the scientific consensus was established during the summer of 2020. High levels of trust in the government and in science and of politicization are associated with belief of HCQ proven inefficacy. Across the whole period, a majority of respondents were uncertain. Even in 2021, 41.5% stated that the data were insufficient to decide whether or not HCQ is effective and 25.2% stating that they did not know.

CONCLUSION

Because media coverage of scientific controversies is higher in times of uncertainty than after these controversies have died down, the publicization of therapeutic promises can have lasting consequences on attitudes towards science and medicine.

摘要

目的

在 2019 年冠状病毒病（COVID-19）大流行的早期阶段，氯喹及其衍生物，如羟氯喹（HCQ），在科学界和媒体中都受到了广泛的关注。本文探讨了影响法国公众对 HCQ 疗效看法的不同因素及其在 2020 年 4 月至 2021 年 6 月期间的演变。

方法

本文利用在法国代表性人群中进行的 5 项调查（项目 COCONEL 和 TRACTRUST；配额法，n=1006；1004；2006；1014 和 1005）。我们询问了关于氯喹对抗 COVID-19 的有效性的问题。我们还收集了社会人口学变量以及对政治和科学的态度。

结果

在 2021 年 4 月至 6 月期间，相信 HCQ 疗效的受访者比例从 35%迅速下降到 14%。认为 HCQ 无效的受访者比例从 6%逐渐上升到 21%。在调整了时间效应后，逻辑回归显示政治取向与相信 HCQ 疗效之间存在很强的关联。与感觉最接近政治中心的受访者相比，感觉最接近更激进政党（极右翼和极左翼）的受访者更有可能相信 HCQ 的疗效（优势比 2.48[1.95-3.15]和 1.87[1.44-2.43]）。在 2020 年夏季科学界达成共识后进行的两次调查中，我们调查了对政府和科学的信任度以及政治参与程度的作用。对政府和科学的高度信任以及政治化与 HCQ 疗效不佳的信念有关。在整个时期，大多数受访者都不确定。即使在 2021 年，仍有 41.5%的人表示数据不足以决定 HCQ 是否有效，25.2%的人表示他们不知道。