羟氯喹啉/氯喹啉作为COVID-19的治疗方法：谜团背后的真相。
Hydroxychloroquine/Chloroquine as Therapeutics for COVID-19: Truth under the Mystery.
作者信息
Chen Yao, Li Mei-Xiu, Lu Guo-Dong, Shen Han-Ming, Zhou Jing
机构信息
Department of Physiology, School of Preclinical Medicine, Guangxi Medical University, Nanning, Guangxi Province, China, 530021.
Department of Toxicology, School of Public Health, Guangxi Medical University, Nanning, Guangxi Province, China, 530021.
出版信息
Int J Biol Sci. 2021 Apr 10;17(6):1538-1546. doi: 10.7150/ijbs.59547. eCollection 2021.
The outbreak of coronavirus disease-19 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly evolved into a global pandemic. One major challenge in the battle against this deadly disease is to find effective therapy. Due to the availability and proven clinical record of hydroxychloroquine (HCQ) and chloroquine (CQ) in various human diseases, there have been enormous efforts in repurposing these two drugs as therapeutics for COVID-19. To date, substantial amount of work at cellular, animal models and clinical trials have been performed to verify their therapeutic potential against COVID-19. However, neither lab-based studies nor clinical trials have provided consistent and convincing evidence to support the therapeutic value of HCQ/CQ in the treatment of COVID-19. In this mini review we provide a systematic summary on this important topic and aim to reveal some truth covered by the mystery regarding the therapeutic value of HCQ/CQ in COVID-19.
由严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）引起的冠状病毒病 19（COVID-19）疫情已迅速演变成一场全球大流行。对抗这种致命疾病的一个主要挑战是找到有效的治疗方法。由于羟氯喹（HCQ）和氯喹（CQ）在各种人类疾病中的可用性和已证实的临床记录，人们在将这两种药物重新用作 COVID-19 的治疗药物方面付出了巨大努力。迄今为止，已经在细胞、动物模型和临床试验方面开展了大量工作，以验证它们对抗 COVID-19 的治疗潜力。然而，无论是基于实验室的研究还是临床试验，都没有提供一致且令人信服的证据来支持 HCQ/CQ 在治疗 COVID-19 方面的治疗价值。在本综述中，我们对这一重要主题进行了系统总结，旨在揭示关于 HCQ/CQ 在 COVID-19 治疗价值这一谜团背后的一些真相。
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