Inoue T, Deporter D A, Melcher A H
J Dent Res. 1986 Jan;65(1):12-22. doi: 10.1177/00220345860650010101.
Induction of chondrogenesis in vivo by rolls of demineralized dentin implanted in muscle, subcutaneous connective tissue of skin, medullary cavity of femur, and periodontal ligament of rat was investigated. Specimens were examined at various times up to 21 days after implantation, using light microscopy and morphometric analysis. Induction of cartilage occurred most quickly in muscle, followed by subcutaneous connective tissue of skin and medullary cavity of femur, and most slowly in periodontal ligament. Significantly more cartilage was found in muscle than in subcutaneous connective tissue of skin and medullary cavity of femur at the times examined, and least of all in periodontal ligament. Outgrowth of cells from rat muscle, dermis and subcutaneous tissue, bone marrow and periodontal ligament cultured in vitro on demineralized bone matrix for up to 35 days produced similar results.
研究了植入大鼠肌肉、皮肤皮下结缔组织、股骨骨髓腔和牙周韧带中的脱矿牙本质卷在体内诱导软骨形成的情况。在植入后长达21天的不同时间对标本进行检查，采用光学显微镜和形态计量分析。软骨诱导在肌肉中发生得最快，其次是皮肤皮下结缔组织和股骨骨髓腔，在牙周韧带中最慢。在所检查的时间点，肌肉中发现的软骨明显多于皮肤皮下结缔组织和股骨骨髓腔，而在牙周韧带中最少。将大鼠肌肉、真皮和皮下组织、骨髓和牙周韧带的细胞在脱矿骨基质上体外培养长达35天，得到了类似的结果。
